Investigating Alternative Nuclear Reactions for Medical Isotope Production

研究医用同位素生产的替代核反应

基本信息

批准号：
10155519
负责人：
Jennifer Anne Shusterman
金额：
$ 15.6万
依托单位：
HUNTER COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2021-08-02
项目状态：
已结题

项目摘要

Investigating Alternative Nuclear Reactions for Medical Isotope Production ABSTRACT The array of radionuclides used for, or considered as good candidates for, nuclear medicine has expanded in recent years. Of these radionuclides 44Sc and 67Cu have shown great promise for use in diagnostic and therapeutic applications, respectively. A challenge associated with translating 44Sc and 67Cu from research scale to long-term medical use is the difficulty in producing each of these radionuclides in large quantities. The production limitation is due to the low cross sections (the probability) of the nuclear reactions that create the purist supply of these isotopes. Since production routes using particle beams commonly used for medical isotopes (protons, neutrons, deuterons) do not result in sufficient cross sections, the proposed work aims to investigate employing heavy ion beam reactions. Heavy ion beams, such as 7Li, offer the potential to produce 67Cu and 44Ti (44Ti is the 44Sc parent) at higher cross sections. The proposed research will focus on the measurement of the cross sections for such reactions. Additionally, post irradiation radiochemistry will be performed so that the final purity of the radionuclides can be compared to the current production methods. Successful demonstration of higher production rates with comparable radionuclide purity will offer an additional production route to make these valuable medical isotopes.

研究医疗同位素生产的替代核反应抽象的用于或被视为良好候选核医学的放射性核素阵列已扩大近年来。在这些放射性核素44SC和67CU中，在诊断和治疗应用。与研究量表翻译44SC和67CU相关的挑战长期的医疗用途是很难大量生产这些放射性核素。这生产限制是由于核反应的低横截面（概率）引起的这些同位素的纯粹供应。由于使用通常用于医疗的粒子梁的生产路线同位素（质子，中子，杜特龙）不会导致足够的横截面，拟议的工作旨在调查采用重离子束反应。重离子梁（例如7LI）提供了产生的潜力在较高的横截面处的67CU和44TI（44TI是44SC父）。拟议的研究将重点放在对此类反应的横截面的测量。此外，放射后放射化学将是进行的，以便可以将放射性核素的最终纯度与当前的生产方法进行比较。成功证明具有可比放射性核素纯度的较高生产率将提供使这些有价值的医疗同位素的其他生产路线。