Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmia

Ryanodine 受体靶向治疗心力衰竭和致死性心律失常

• 批准号: 15K09142
• 负责人: KOBAYASHI Shigeki
• 金额: $ 3.16万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09142/
• 关键词: ryanodine receptor; heart failure; arrhythmia; dantrolene; リアノジン受容体; 心不全; 心室頻拍; カルシウムハンドリング; ダントロレン; 拡張不全; 高血圧; 弛緩障害

项目成果

Myocardial Oxidative Stress, Urinary 8-hydroxy-2’-deoxyguanosine, is Associated With Sustained Ventricular Tachycardia in Patient With Active Cardiac Sarcoidosis

心肌氧化应激、尿 8-羟基-2’-脱氧鸟苷与活动性心脏结节病患者持续性室性心动过速相关

• 发表时间: 2016
• 作者: Hironori Ishiguchi;Shigeki Kobayashi;Michiaki Kohno;Takuma Nanno;Takeki Myoren;Seiko Oda;Hiroki Tateishi;Mamoru Mochizuki;Tetsuro Oda;Jutaro Yamada;Takayuki Okamura;Masafumi Yano
• 通讯作者: Masafumi Yano

A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.

• DOI: 10.1371/journal.pone.0114314
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kobayashi S;Susa T;Ishiguchi H;Myoren T;Murakami W;Kato T;Fukuda M;Hino A;Suetomi T;Ono M;Uchinoumi H;Tateishi H;Mochizuki M;Oda T;Okuda S;Doi M;Yamamoto T;Yano M
• 通讯作者: Yano M

Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy.

章鱼壶心肌病患者心肌氧化应激与心脏交感神经亢进的关系

• 发表时间: 2016
• 期刊: Bulltin of the Yamaguchi Medical School
• 作者: Seiko Oda;Shigeki Kobayashi;Takuma Nanno;Hironori Ishiguchi;Takeki Myoren;Wakako Murakami;Mamoru Mochizuki;Tetsuro Oda;Shinichi Okuda;Jutaro Yamada;Takayuki Okamura;Masunori Matsuzaki;Masafumi Yano.
• 通讯作者: Masafumi Yano.

Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure

在没有钙调蛋白的情况下，丹曲林无法抑制压力过载心力衰竭中的异常 Ca2 释放和心律失常

• 发表时间: 2015
• 作者: Zhan H;Aizawa K;Sun JQ;Tomida S;Otsu K;Conway S;McKinnon P;Manabe I;Komuro I;Miyagawa K;Nagai R;Suzuki T;Go Fukui，Takeshi Yamamoto，Tkayoshi Kato，Takako Maeda，Shigehiko Nishimura，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano
• 通讯作者: Go Fukui，Takeshi Yamamoto，Tkayoshi Kato，Takako Maeda，Shigehiko Nishimura，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano

ダントロレンによるリアノジン受容体を分子標的とした心不全・不整脈治療の臨床応用

以兰尼定受体为分子靶点丹曲林治疗心力衰竭和心律失常的临床应用

• 发表时间: 2016
• 作者: 武田憲文;原弘典;小室一成.;Shigeki Kobayashi
• 通讯作者: Shigeki Kobayashi