Evaluation of genetical factor in the Japanese is chemic heart disease

日本人化学性心脏病遗传因素评价

基本信息

批准号：
09670743
负责人：
NAKAI Kenji
金额：
$ 1.92万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Coronary artery disease including acute myocardial infarction is a major cause for cardiac sudden death. The pathogenesis and genetical risk factor of coronary artery disease and acute myocardial infarction have not been fuilly elucidated. The clinical research regarding genetical factors in the Japanese were worthy of note in the world, because the frequencies of several gene polymorphism were different with those in Caucasian. The purpose of this study is to evaluate the significance of genetical factors such as apolipoprotein E (apo E), angiotensin II type 1 receptor, ecNOS, and methylenetetrahydrofolate reductase (MTHFR) in the occurrence of myocardial infarction.Results: 1) The frequency of polymorphism of apo E ε4 allele and ATR1 All66C mutation [AC+CC] in the Japanese healthy population was lesser than those in Caucasian healthy population. 2) The frequency of apo E ε 4 allele and ATR1 A1166C mutation [AC+CC], esNOS 4a/a with tandem repeat, and MTHFR alanine/valine (A/V) caused by C677T mutation in the myocardial infarction were greater than those in Japanese healthy population (apo E; Nakai et al, Coronary Artery Dis, 1999). 3) Thee levels of concentration of homocysteine in MTHFR gene VV type was higher than that in other AV and AA genotype (11.6 ± 5.6 μmol/L in VV type, 8.9 ± 4.1 μmol/L in AV type and 8.6 ± 3.3 μmol/L in AA type) (Nakai K et al: Coronary Artery Dis, 1999). 4) The frequency of ATRI A1166C mutation [AC+CC] in the myocardial infarction was higher than that in healthy population (Fusazaki et al; Eur heart J, 1999).In conclusion, apo E e4 allele, A1166C mutation [AC+CC], MTHFR geneVV type were predisposition for myocardial infarction. In future, these genetical analysis enable to indicate for primary or secondary prevention for myocardial infarction or coronary artery disease.

包括急性心肌梗塞在内的冠状动脉疾病是心脏猝死的主要原因。冠状动脉疾病和急性心肌梗塞的发病机理和遗传危险因素尚未完全阐明。关于日本遗传因素的临床研究在世界上是宝贵的，因为几种基因多态性的频率与高加索人的频率不同。这项研究的目的是评估通用因素（例如载脂蛋白E（Apo e），血管紧张素II型受体，eCNOS和甲基苯甲酸甲基氢叶酸）还原（MTHFR）的重要性健康人群比白人健康人群的人群少。 2）apoeε4等位基因和ATR1 A1166C突变[AC+CC]，ESNOS 4A/A具有串联重复的频率，以及由C677T突变引起的MTHFR Alanine/Valine（A/V）在心肌梗死中引起的C677T突变引起的频率大于日本健康人群中的c677t突变（apo e; apo e; apo e; nakai et; nakai等，coronary aronary aronary arttery dien coronary arttery arttery arttery arttery arttery arttery arttery arttery arttery arttery arttery arttery，1999）。 3）MTHFR基因VV类型中的浓度高半胱氨酸浓度水平高于其他AV和AA基因型（11.6±5.6μmol/L的VV类型为11.6±5.6μmol/L，AV类型为8.9±4.1 µmol/L，在AA类型中为8.6±3.3 µmol/L。 4）心肌违规中ATRI A1166C突变[AC+CC]的频率高于健康人群的频率（Fusazaki等人； Eur Heart J，1999）。总之，Apo E E4等位基因，A1166C突变[AC+CC]，MTHFR GeneVV类型是心肌违规的倾向。将来，这些通用分析可以指示用于心肌梗塞或冠状动脉疾病的初级或次要预防。