Effect of sex hormone on oxalate synthesizing enzyme in male and female rat livers.

性激素对雄性和雌性大鼠肝脏草酸合成酶的影响。

• 批准号: 09671599
• 负责人: YACHIKU Sunao
• 金额: $ 1.66万
• 依托单位: Asahikawa medical college
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671599/
• 关键词: oxalate metabolism; enzymes; sex hormone; ethylene glycol; urinary calculi; テストステロン; エチレングルコール; ラット; エストロゲン; シュウ酸カルシウム

Ethylene glycol and glycolate increased urinary oxalate concentration in male rats dose-dependently but less in female rats. There was almost no change during glycine loading in either male or female rats. GO activity was significantly lower in intact female and gonadectomized male rats. SPT activity was slightly higher in the female than in the male controls. There were no differences in urinary oxalate excretions between male and female rats. During ethylene glycol loading, GO and SPT activities were similar to those with tap water intake. However, urinary oxalate excretion increased to two times the control value in male rats but only slightly increased in female rats. Sex-related differences exist in the metabolic conversion of glycolate to oxalate in rats, and GO activity is promoted by testosterone. Although difference in GO activity has no physiological effect on oxalate synthesis, GO activity affects urinary oxalate excretion during ethylene glycol loading. We could also conclude that estrogen decreases GO activity in male rats from our results.

乙二醇和乙酸乙二醇升高雄性大鼠剂量依赖性但雌性大鼠的草酸含量较少。男性或雌性大鼠的甘氨酸载荷中几乎没有变化。完整的女性和性腺切除型雄性大鼠的GO活性明显降低。女性的SPT活性略高于男性对照组。雄性大鼠和雌性大鼠的草酸尿素排泄没有差异。在乙二醇载荷期间，GO和SPT活动与自来水摄入量相似。然而，草酸尿液排泄增加到雄性大鼠的控制值的两倍，但在雌性大鼠中仅略有增加。与性别相关的差异存在于大鼠乙醇酸的代谢转化率中，而GO活性由睾丸激素促进。尽管GO活性的差异对草酸盐的合成没有生理影响，但GO活性会影响乙烯乙二醇载荷期间的草酸盐排泄。我们还可以得出结论，雌激素从我们的结果中减少了雄性大鼠的活性。

项目成果

森川満、八竹直他: "尿路結石症における男女差の検討" 日本泌尿器科学会雑誌. 89・5. 538-545 (1998)

Mitsuru Morikawa、Nao Yatake 等：“尿石症的性别差异检查”日本泌尿外科协会杂志 89・5（1998 年）。

山口聡、八竹直: "腎・尿管結石" 総合臨床. 46・増. 499-504 (1997)

Satoshi Yamaguchi，Nao Yatake：“肾/输尿管结石”一般临床实践 46，放大版 499-504 (1997)。

Hideki Yoshihara, Sunao Yachiku et.al.: "Effect of sex hormone on oxalate-synthesizing enzymes in male and female rat livers." Journal of Urology.161(2). 668-673 (1999)

Hideki Yoshihara、Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏草酸合成酶的影响。”

Hideki Yoshihara,Sunao Yachiku et al: "Effect of sexhormone on oxalate-synthesizing enzymes in male and female rat livers" Journal of Urology. 161・2. 668-673 (1999)

Hideki Yoshihara、Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏草酸合成酶的影响”泌尿学杂志 161・2（1999）。

Hideki Yoshihara Sunao Yachiku et.al: "Effect of sex hormone on oxalafe-synthesizing enzymes in male and female rat livers" Journal of Urology. 161・2. 668-673 (1999)

Hideki Yoshihara Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏中草酸合成酶的影响”泌尿学杂志 161・2（1999）。