Role of CDC42 in pro-inflammatory phenotype of senescent vascular endothelial cells

CDC42在衰老血管内皮细胞促炎表型中的作用

• 批准号: 24790272
• 负责人: ITO Takashi
• 金额: $ 2.83万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790272/
• 关键词: 慢性炎症; 細胞老化; 血管内皮細胞; CDC42; 動脈硬化; 寿命; 老化; PAK2; 個体老化

Chronic inflammation underlies most age-related diseases such as cancer, cardiovascular disease, and neurodegenerative disorder. This research focuses on a phenomenon called cellular senescence, in which multiple genes associated with inflammation are upregulated. We identified CDC42 as a regulator of inflammatory genes in senescent vascular cells, and also as a regulator of atherosclerosis in mice. CDC42 was the cause of short lifespan of mutant worms with immune over activation, a model for chronic inflammation of mammals. These results suggest that CDC42 has a critical role in chronic inflammation and age-related diseases.

慢性炎症是大多数与年龄相关的疾病的基础，例如癌症、心血管疾病和神经退行性疾病。这项研究重点关注一种称为细胞衰老的现象，其中与炎症相关的多个基因被上调。我们确定CDC42是衰老血管细胞中炎症基因的调节剂，也是小鼠动脉粥样硬化的调节剂。 CDC42是免疫过度激活的突变蠕虫寿命短的原因，这是哺乳动物慢性炎症的模型。这些结果表明 CDC42 在慢性炎症和年龄相关疾病中发挥着关键作用。

项目成果

CDC42 and NFκB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells

CDC42 和 NFκB 信号传导有助于衰老内皮细胞的促炎表型

• 发表时间: 2012
• 作者: Ito T; Minamino T
• 通讯作者: Minamino T

CDC42 and NFκB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells

CDC42 和 NFκB 信号传导有助于衰老内皮细胞的促炎表型

• 发表时间: 2012
• 作者: Ito T; Minamino T
• 通讯作者: Minamino T

CDC42経路が老化血管内皮細胞の炎症誘導を制御する

CDC42通路控制衰老血管内皮细胞的炎症诱导

• 发表时间: 2013
• 作者: 伊藤孝; 南野徹
• 通讯作者: 南野徹

CDC42経路が老化血管内皮細胞の炎症誘導を制御する

CDC42通路控制衰老血管内皮细胞的炎症诱导

• 作者: 伊藤 孝

老化血管内皮細胞による炎症誘導にCDC42経路とNFκB経路が寄与する

CDC42通路和NFκB通路有助于衰老血管内皮细胞诱导炎症

• 发表时间: 2012
• 作者: 伊藤孝; 南野徹
• 通讯作者: 南野徹