Revealing structural basis for development of a novel drug against multidrug-resistant HIV

揭示开发抗多重耐药艾滋病毒新药的结构基础

• 批准号: 24790049
• 负责人: suzuki kaoru
• 金额: $ 2.91万
• 依托单位: Iwaki Meisei University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790049/
• 关键词: HIV感染; 抗HIV薬; タンパク質; 糖鎖; レクチン; Ｘ線結晶構造解析; 感染症; 薬学; ＨＩＶ感染; ＨＩＶ感染予防; HIV感染予防; X線; 構造解析; 構造薬学

项目成果

Structural insights of a potent anti-HIV actinohivin upon binding specifically to the target oligomannose of HMTG attached to HIV-gp120

强效抗 HIV 放线菌素与 HIV-gp120 上附着的 HMTG 目标寡甘露糖特异性结合后的结构见解

• 发表时间: 2012
• 作者: 角田大

Structural insights into the specific anti-HIV property of actinohivin; Crystal structure of its complex with the alpha(1-2)mannobiose moiety of gp120

放线菌素与 gp120 的 α(1-2) 甘露二糖部分复合物的晶体结构的结构见解；

• DOI: 10.1107/s0907444912040498
• 发表时间: 2012
• 作者: M. Mominul Hoque; Kaoru Suzuki; Masaru Tsunoda; Ji;ong Jiang; Fang Zhang; Atsushi Takahashi; Naomi Ohbayashi; Xiaoxue Zhang; Haruo Tanaka; Satoshi Omura;Akio Takenaka
• 通讯作者: Akio Takenaka

Crystallographic study of the interaction of the anti-HIV lectin actinohivin with the alpha(1-2)mannobiose moiety of gp120 HMTG

抗 HIV 凝集素放线菌素与 gp120 HMTG 的 α(1-2) 甘露二糖部分相互作用的晶体学研究

• DOI: 10.1107/s1744309112031077
• 发表时间: 2012
• 作者: Kaoru Suzuki; Naomi Ohbayashi; Ji;ong Jiang; Xiaoxue Zhang; M. Mominul Hoque; Masaru Tsunoda; Kazutaka Murayama; Haruo Tanaka;Akio Takenaka
• 通讯作者: Akio Takenaka

Structural analyses of actinohivin with glucan for development of HIV preventer

放线菌素与葡聚糖的结构分析用于开发艾滋病毒预防剂

• 发表时间: 2014
• 作者: Masaru Tsunoda; Kaoru Suzuki; Yoichi Takeda;Yukishige Ito
• 通讯作者: Yukishige Ito

Peculiarity in crystal packing of anti-HIV lectin actinohivin in complex with α(1-2)mannobiose

抗 HIV 凝集素放线菌素与 α(1-2) 甘露二糖复合物晶体堆积的特殊性

• DOI: 10.1107/s0907444913017812
• 发表时间: 2013
• 作者: Kaoru Suzuki; Masaru Tsunoda; M. Mominul Hoque; Fang Zhang; Ji;ong Jiang; Xiaoxue Zhang; Naomi Ohbayashi; Haruo Tanaka & Akio Takénaka
• 通讯作者: Haruo Tanaka & Akio Takénaka