The Regeneration of cementum by Using Cementoblast

利用成牙骨质细胞再生牙骨质

• 批准号: 23792235
• 负责人: SHINOHARA YOSHINORI
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792235/
• 关键词: 再生医療; 補綴装置; セメント質; 再生歯学; 歯原性上皮細胞; マラッセの上皮遺残細胞

At present prosthesis treatments such as crown/bridge, removable denture and dentalimplant are commonly performed. On the other hand, trauma or congenital/aquiried tooth defect is stored by artificial materials have various issues in terms of biocompability, esthetics, functoionality, compared to natural teeth. This study delineates how regenerative therapy is applied to clinical dentistry. As a first step, we examined tooth regeneration which applied tissue engineering technique, especially cementum regeneration and tooth prosthesis materials. Recently, it is found that not only does cementum regenetration take a long period to complete tissue regeneration but also turnregenerated tissue premature and small. This research examines how cultured odontogenic cell stratification will affect the ability of cell growth and differentiation and tissue regeneration. Then, it intends to prove cell culture and tissue regeneration method quantitavely and qualitively.

目前常用的修复治疗有牙冠/牙桥、活动义齿、种植牙等。另一方面，与天然牙齿相比，由人造材料存储的外伤或先天/后天牙齿缺陷在生物相容性、美观性、功能性方面存在各种问题。这项研究描述了再生疗法如何应用于临床牙科。作为第一步，我们研究了应用组织工程技术的牙齿再生，特别是牙骨质再生和牙齿修复材料。近年来发现牙骨质再生不仅需要较长的时间才能完成组织再生，而且使再生的组织过早变小。这项研究探讨了培养的牙源细胞分层如何影响细胞生长、分化和组织再生的能力。然后，拟对细胞培养和组织再生方法进行定量和定性证明。