Vitamin E derivative ETS-GS reduces liver ischemia-reperfusion injury in rats.

维生素 E 衍生物 ETS-GS 可减轻大鼠肝脏缺血再灌注损伤。

• 批准号: 23791717
• 负责人: YAMAMOTO Shunsuke
• 金额: $ 2.58万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791717/
• 关键词: 肝虚血再還流傷害; 抗酸化物質; ビタミンE誘導体; ETS-GS; 肝臓虚血再灌流傷害; 虚血再灌流障害

In the present study, we evaluated the ability of a new vitamin E derivative, ETS-GS, to improve liver I/R injury.Male Wistar Rats received a subcutaneous injection of ETS-GS (10 mg/kg) or saline before experimentally-induced liver I/R injury or sham treatment. The rats were sacrificed after the 60-min ischemia and 24-h reperfusion. We found that ETS-GS treatment attenuated I/R-induced histologic alterations, reduced levels of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH). Taken together, our results demonstrate that ETS-GS attenuates I/R injury in a rat model and suggests that ETS-GS may exert anti-oxidant effects. Accordingly, ETS-GS may have therapeutic potential to treat various clinical conditions involving I/R injury.

在本研究中，我们评估了一种新的维生素 E 衍生物 ETS-GS 改善肝缺血再灌注损伤的能力。雄性 Wistar 大鼠在实验前接受皮下注射 ETS-GS (10 mg/kg) 或盐水。诱导肝 I/R 损伤或假治疗。 60分钟缺血和24小时再灌注后处死大鼠。我们发现 ETS-GS 治疗减轻了缺血再灌注引起的组织学改变，降低了肝酶天冬氨酸转氨酶 (AST)、丙氨酸转氨酶 (ALT) 和乳酸脱氢酶 (LDH) 的水平。综上所述，我们的结果表明 ETS-GS 可以减轻大鼠模型中的 I/R 损伤，并表明 ETS-GS 可能发挥抗氧化作用。因此，ETS-GS 可能具有治疗涉及 I/R 损伤的各种临床病症的治疗潜力。