Role of kinin receptors in obesity and leptin signaling

激肽受体在肥胖和瘦素信号传导中的作用

• 批准号: 61478590
• 负责人: Professor Dr. Michael Bader
• 金额: --
• 依托单位: Forschungsgruppe Molekularbiologie von Hormonen im Herz-Kreislaufssystem
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/61478590?language=en
• 关键词: Role; kinin; receptors; obesity; leptin

The kallikrein-kinin system (KKS) is a peptide hormone system involved in the regulation of smooth muscle contraction, endothelium-dependent vasodilatation, nociception and inflammation. Two receptors transmit the actions of the kinin peptides, B1 and B2. We could recently show that the kinin B1 receptor is crucially involved in leptin signalling and, thus, B1 deficient mice were resistant to high fat diet induced obesity. Using established and newly generated transgenic and knockout mouse models, this project plans to clarify the cell types involved in the interactions between the B1 receptor and leptin, and further investigates the role of the B2 receptor as well as the whole KKS in these processes. The final aim is to evaluate the two kinin receptors as targets for novel anti-obesity therapeutics. The project is jointly performed by the group of the applicant together with the group of Prof. Joǎo B. Pesquero from the Federal University of Sǎo Paulo, Brazil.

激肽释放酶-激肽系统 (KKS) 是一种肽激素系统，参与平滑肌收缩、内皮依赖性血管舒张、伤害感受和炎症的调节，我们最近可以证明，两种受体传递激肽肽 B1 和 B2 的作用。激肽 B1 受体在瘦素信号传导中发挥着至关重要的作用，因此，B1 缺陷小鼠能够抵抗高脂肪饮食诱导的肥胖。在小鼠模型中，该项目计划阐明参与 B1 受体和瘦素之间相互作用的细胞类型，并进一步研究 B2 受体以及整个 KKS 在这些过程中的作用，最终目的是评估这两种激肽。该项目由申请人团队与巴西圣保罗联邦大学的 Joǎo B. Pesquero 教授团队联合开展。