Development of regenerative therapy of cementum to the gap of vertical root fracture and interdigitation to the resin

牙骨质对牙根垂直骨折间隙及树脂交指再生治疗的进展

• 批准号: 23592789
• 负责人: SUGAYA Tsutomu
• 金额: $ 2.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592789/
• 关键词: ４-META/MMA-TBBレジン; 炭酸カルシウム; αＴＣＰ; 骨接触率; 骨形成; ハイブリッド; BMP; 骨接触; 骨髄; ナノハイドロキシアパタイト; 接着強さ; カルシウム溶出; 象牙質吸収

4META/MMA-TBB resin and calcium carbonate or TCP were made composition, and elution of Ca2+ was measured. Ca2+ elution of all samples increased as the concentration becomes higher. That of beta-TCP had less than alpha-TCP and calcium carbonate. 4META/MMA-TBB resin containing alpha-TCP can facilitate direct contact between the resin and newly formed born. The hybrid layer with the bone marrow was formed on the resin surface when resin was cured in bone marrow, and the rate of bone-resin contact improved. BMP soaked collagen menbrane-nanohydroxyapatite composition was put on dentin and implanted in a femoral musle. Then a high percentage of hard tissue formation to the dentin surface was provided. 4META/MMA-TBB resin containing alpha-TCP was adhered on root surface, and BMP soaked collagen menbrane-nanohydroxyapatite composition was put on the resin. The hard tissue formation was observed on the resin.

将4META/MMA-TBB树脂与碳酸钙或TCP组合，测定Ca2+的溶出量。所有样品的 Ca2+ 洗脱随着浓度变高而增加。 β-TCP的含量低于α-TCP和碳酸钙。 4META/MMA-TBB树脂中含有α-TCP可以促进树脂与新形成的树脂之间的直接接触。当树脂在骨髓中固化时，在树脂表面形成与骨髓的混合层，提高了骨与树脂的接触率。将BMP浸泡的胶原膜-纳米羟基磷灰石组合物置于牙本质上并植入股骨肌中。然后在牙本质表面提供高百分比的硬组织形成。将含有α-TCP的4META/MMA-TBB树脂粘附在根面，并在树脂上放置BMP浸泡的胶原膜-纳米羟基磷灰石组合物。在树脂上观察到硬组织形成。

项目成果

ナノハイドロキシアパタイトがBMP-2による硬組織形成と象牙質吸収に及ぼす影響

纳米羟基磷灰石对BMP-2诱导的硬组织形成和牙本质吸收的影响

• 发表时间: 2011
• 作者: 玉川博貴;西尾啓英;中澤篤史;菅谷勉;川浪雅光
• 通讯作者: 川浪雅光

Osteoinductiveity and biodegradability of collagen scaffold coated with Nano-β-TCP and fibroblast groueth factor 2

Nano-β-TCP和成纤维细胞因子2包覆胶原支架的骨诱导性和生物降解性

• DOI: 10.1155/2013/639502
• 发表时间: 2014
• 作者: Ibara A; Miyaji H; Fugetsu B; Nshida E; Takita H; Tanaka S; Sugaya T; Kawanami M
• 通讯作者: Kawanami M

骨髄液内で硬化させた4-META/MMA-TBBレジン表面への硬組織形成

骨髓液中固化的4-META/MMA-TBB树脂表面硬组织形成

• 作者: 洲崎真希;菅谷 勉;中塚 愛;柳沢 剛;川浪雅光
• 通讯作者: 川浪雅光

北海道大学大学院歯学研究科歯周・歯内療法学教室研究業績

北海道大学大学院齿科研究科牙周病牙髓病学研究成果

骨髄液内で硬化させた4-META/MMA-TBBレジン表面への硬組織形成

骨髓液中固化的4-META/MMA-TBB树脂表面硬组织形成

• 发表时间: 2013
• 作者: 洲崎真希;菅谷勉;中塚愛;柳沢剛;川浪雅光
• 通讯作者: 川浪雅光