Study of cerebral cortical mechanisms possibly responsible for jaw-movement disorders

可能导致下颌运动障碍的大脑皮层机制的研究

• 批准号: 23592699
• 负责人: YOSHIDA Atsushi
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592699/
• 关键词: 顎運動; 三叉神経運動核; 運動ニューロン; 大脳皮質; 脳; 神経; 解剖; 歯学; 咀嚼; 顎; 抑制性ニューロン; 頤

Electrical stimulation of the primary somatosensory cortex and the lateral part of the prefrontal cortex (insular cortex) as well as the lateral part of the agranular cortex induced jaw-movements which are specific for the cortical location stimulated. However, stimulation of the medial part of the agranular cortex did not induce any jaw-movements. These cortical areas sent direct projections to the trigeminal sensory nuclear complex and the reticular formation around the trigeminal motor nucleus both of which include excitatory and/or inhibitory premotoneurons. Note that such premotoneurons were also found in the solitary tract nucleus.These results may indicate that several indirect projections from the cerebral cortical areas to the trigeminal motor nucleus via its premotoneurons are involved in the induction of the characteristic jaw-movements, and the jaw-movement disorders are attributed to the disorders of the indirect projection systems from the cerebral cortical areas.

对初级体感皮层和前额叶皮层（岛叶皮层）的外侧部分以及无颗粒皮层的外侧部分的电刺激引起下颌运动，该运动对于所刺激的皮层位置是特定的。 然而，刺激无颗粒皮层的内侧部分不会引起任何下巴运动。 这些皮质区域向三叉神经感觉核复合体和三叉神经运动核周围的网状结构发送直接投射，这两者都包括兴奋性和/或抑制性前运动神经元。 请注意，这种前运动神经元也在孤束核中发现。这些结果可能表明，从大脑皮层区域通过其前运动神经元到三叉神经运动核的几个间接投射参与了特征性下颌运动的诱导，并且下颌运动运动障碍归因于大脑皮层区域的间接投射系统的障碍。

项目成果

Projections to the trigeminal jaw-opening and jaw-closing premotoneurons in the nucleus of the solitary tract from the pharyngeal mucosa and the insular cortex in rats

大鼠咽粘膜和岛叶皮质孤束核中三叉神经开颌和闭颌前运动神经元的投影

• 发表时间: 2012
• 作者: A OKA; R TAKEDA; F SATO; F AKHTER; TL HAQUE; T KATO; H OHARA; Y
• 通讯作者: Y

大脳皮質一次および二次体性感覚野から三叉神経感覚核への投射の差異の解明

阐明从大脑皮层的初级和次级体感区域到三叉神经感觉核的投射差异

• 发表时间: 2012
• 作者: Tahsinul Haque;Fatema Akhter;佐藤文彦;加藤隆史;岡綾香;Barry J Sessle;吉田篤
• 通讯作者: 吉田篤

Differences in projections from the primary and secondary sonatosensory cortex to the trigeminal sensory nuclear complex in the rat

大鼠初级和次级声感觉皮层到三叉神经感觉核复合体的投射差异

• 作者: T Haque; F Sato; A Oka; R Takeda; F Akhter; M. Higashiyama; T Kato; A Yoshida
• 通讯作者: A Yoshida

γ-aminobutyric acid-, glycine-, and glutamate-immunopositive boutons on mesencephalic trigeminal neurons that innervate jaw-closing muscle spindles in the rat: ultrastructure and development.

γ-氨基丁酸、甘氨酸和谷氨酸免疫阳性布顿对中脑三叉神经元的影响，这些神经元支配大鼠的下颌闭合肌梭：超微结构和发育。

• DOI: 10.1002/cne.23110
• 发表时间: 2012
• 影响因子: 2.5
• 作者: Paik SK; Kwak MK; Bae JY; Yi HW; Yoshida A; Ahn DK; Bae YC
• 通讯作者: Bae YC

Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats

大鼠从初级体感皮层口面部区域到脑桥和髓质，特别是三叉神经感觉核复合体的体位直接投射

• DOI: 10.1016/j.neuroscience.2011.10.048
• 发表时间: 2012
• 影响因子: 3.3
• 作者: A Tomita; T Kato; F Sato; T Haque; A Oka; M Yamamoto; T Ono; Y
• 通讯作者: Y