Therapeutic effect improvement by new boron neutron capture therapy with amino acid - BSH

新型氨基酸硼中子俘获疗法改善疗效 - BSH

• 批准号: 23592146
• 负责人: KAWABATA Shinji
• 金额: $ 3.41万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592146/
• 关键词: 脳腫瘍学; 悪性神経膠腫; 放射線治療; ホウ素化合物; 中性子捕捉療法; 合成アミノ酸; ドラッグデリバリーシステム

Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive Boron-10 is irradiated with low energy thermal neutrons to produce alpha- particles inside one cell level. The L-amino acid transport system in tumor cells is enhanced compared with normal cells. We designed, synthesized and tested boron carrying unnatural amino-acid, ACBC-BSH, as boron drug for BNCT. Curative effect of ACBC-BSH groups was approximately equal to BPA. The reason is that we think that extracellular accumulations of ACBC-BSH indicating that the seemingly high tumor boron concentrations did not represent the true tumor cellular uptake. And we did not compete for the curative effect by using ACBC-BSH together in BPA and accepted meaningful duration of survival time. Difference in drug distribution at the cell level was regarded as the cause. This study suggested the possibility that ACBC-BSH became the drug to add curative effect to.

硼中子俘获疗法 (BNCT) 是基于用低能热中子照射非放射性硼 10 时发生的核俘获和裂变反应，在一个细胞水平内产生 α 粒子。与正常细胞相比，肿瘤细胞中的L-氨基酸转运系统增强。我们设计、合成并测试了携带非天然氨基酸的硼 ACBC-BSH，作为 BNCT 的硼药物。 ACBC-BSH组的疗效与BPA大致相当。原因是我们认为 ACBC-BSH 的细胞外积累表明看似高的肿瘤硼浓度并不代表真正的肿瘤细胞摄取。我们并没有竞争ACBC-BSH在BPA中联合使用的疗效，并接受了有意义的生存时间。细胞水平上药物分布的差异被认为是原因。本研究提示ACBC-BSH成为附加疗效药物的可能性。

项目成果

Boron neutron capture therapy for recurrent high-grade meningiomas

硼中子俘获疗法治疗复发性高级别脑膜瘤

• 发表时间: 2013
• 影响因子: 4.1
• 作者: Kawabata S

ホウ素中性子捕捉療法による悪性髄膜腫の治療成績

硼中子俘获疗法治疗恶性脑膜瘤的结果

• 发表时间: 2013
• 作者: 川端信司;平松亮
• 通讯作者: 平松亮

悪性脳腫瘍の治療.放射線治療のトピックス.ホウ素中性子捕捉療法

恶性脑肿瘤的治疗主题。

• 发表时间: 2013
• 作者: 川端信司;平松亮;宮武伸一
• 通讯作者: 宮武伸一

Repeated treatments with bevacizumab for recurrent radiation necrosis in patients with malignant brain tumors: a report of 2 cases

贝伐珠单抗重复治疗恶性脑肿瘤复发性放射性坏死2例报告

• DOI: 10.1007/s11060-010-0333-3
• 发表时间: 2011
• 影响因子: 3.9
• 作者: Furuse M

大阪医科大学における脳腫瘍治療例の報告(悪性髄膜腫)

大阪医科大学脑肿瘤治疗报告（恶性脑膜瘤）

• 发表时间: 2013
• 作者: 川端信司.