Clinical application of the minimal residual disease monitoring in canine lymphoma

微小残留病监测在犬淋巴瘤中的临床应用

• 批准号: 23380182
• 负责人: TSUJIMOTO Hajime
• 金额: $ 11.65万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380182/
• 关键词: 動物; 犬; リンパ腫; 微小残存病変; 化学療法; 予後

Overall survival durations after standard chemotherapies have been reported as long as 1 year. In the present study, we assessed the efficacy of the chemotherapeutic protocols objectively by quantification of the minimal residual disease, MRD, after chemotherapy with real-time PCR. Through the results of MRD monitoring, we could propose several strategies to improve the chemotherapeutic protocols such as dose change of the drugs, requirement of the consolidation chemotherapy, and the necessity of the early re-induction chemotherapy during complete remission. The present studies were conceivably very helpful to improve the chemotherapeutic modalities for canine lymphoma as well as indicative of the usefulness of canine lymphoma as an animal model for human non-Hodgkin lymphoma.

据报道，标准化疗后的总生存期长达 1 年。在本研究中，我们通过实时 PCR 量化化疗后的微小残留病 (MRD) 来客观评估化疗方案的疗效。通过MRD监测结果，我们可以提出一些改进化疗方案的策略，例如药物剂量的改变、巩固化疗的要求以及完全缓解期间早期再诱导化疗的必要性。可以想象，目前的研究对于改善犬淋巴瘤的化疗方式非常有帮助，并表明犬淋巴瘤作为人类非霍奇金淋巴瘤动物模型的有用性。

项目成果

イヌのリンパ腫治療の現状

犬淋巴瘤治疗现状

• 发表时间: 2012
• 作者: 辻本元

Antitumour effect and modulation of expression of ABCB1 gene by perifosine in canine lymphoid tumour cell lines.

哌立福辛在犬淋巴肿瘤细胞系中的抗肿瘤作用和 ABCB1 基因表达的调节。

• DOI: 10.1016/j.tvjl.2014.04.002
• 发表时间: 2014
• 作者: Tomiyasu; H.; Goto;Tsujimoto; H.
• 通讯作者: H.

Establishment of five canine lymphoma cell lines and tumor formation in a xenotransplantation model.

五种犬淋巴瘤细胞系的建立和异种移植模型中的肿瘤形成。

• 发表时间: 2013
• 影响因子: 1.2
• 作者: Umeki; S.; Ema; Y.; Suzuki; R.; Kubo; M.; Hayashi; T.; Okamura; Y.; Yamazaki; J.; Tsujimoto; H.; Tani; K.; Hiraoka; H.; Okuda; M.;Mizuno; T.
• 通讯作者: T.

GeneScanning analysis of antigen receptor gene rearrangement in the intestinal endoscopic biopsy specimens and its application to the diagnosis of small cell lymphoma in dogs

GeneScanning分析肠内镜活检标本中抗原受体基因重排及其在犬小细胞淋巴瘤诊断中的应用

• 发表时间: 2013
• 作者: S. Hiyoshi; K. Uchida; K. Nakashima; K. Fukushima; H. Kanemoto; Y. Goto; Y. Fujino; K. Ohno; H. Tsujimoto
• 通讯作者: H. Tsujimoto

Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells.

在犬淋巴肿瘤细胞中通过启动子高甲基化抑制 p16 肿瘤抑制基因的表达。

• DOI: 10.1016/j.rvsc.2014.04.008
• 发表时间: 2014
• 影响因子: 2.4
• 作者: Fujiwara;Tsujimoto; H.
• 通讯作者: H.