New therapeutic strategy for refractory ovarian carcinoma based on function of Glypican-3

基于Glypican-3功能的难治性卵巢癌治疗新策略

• 批准号: 22791526
• 负责人: UMEZU Tomokazu
• 金额: $ 2.5万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791526/
• 关键词: 卵巣癌; 明細胞腺癌; Glypican-3; 予後; 抗体療法; IGF-II; GC33; グリピカン3; 免疫療法; PBMC

We previously reported that Glypican-3, a heparan sulfate proteoglycan, was overexpressed in clear cell carcinoma of ovary. We evaluated function of Glypican-3 in clear cell carcinoma of ovary. We showed that Glypican-3 was associated with cell growth inhibition in IGF-II dependent way through PI3K/AKT axis.Glypican-3 expression was associated with short progression-free survival in early stage clear cell carcinoma of ovary patients. We evaluated cytotoxicity of the anti-Glypican-3 antibody. Although cytotoxicity of the anti Glypican-3 antibody was confirmed in vitro, no longer survival time was seen by combination therapy of paclitaxel and anti Glypican-3 antibody in vivo.

我们之前报道过 Glypican-3（一种硫酸乙酰肝素蛋白聚糖）在卵巢透明细胞癌中过度表达。我们评估了 Glypican-3 在卵巢透明细胞癌中的功能。我们发现，Glypican-3 通过 PI3K/AKT 轴以 IGF-II 依赖性方式与细胞生长抑制相关。Glypican-3 表达与早期卵巢透明细胞癌患者的短期无进展生存期相关。我们评估了抗 Glypican-3 抗体的细胞毒性。尽管在体外证实了抗Glypican-3抗体的细胞毒性，但在体内紫杉醇和抗Glypican-3抗体的联合治疗并未观察到更长的存活时间。

项目成果

Postrecurrent oncologic outcome of patients with ovarian clear cell carcinoma

卵巢透明细胞癌患者复发后的肿瘤学结果

• 发表时间: 2012
• 影响因子: 4.8
• 作者: Kajiyama H; Shibata K; Mizuno M; Yamamoto E; Fujiwara S; Umezu T; Suzuki S; Nakanishi T; Nagasaka T; Kikkawa F
• 通讯作者: Kikkawa F

Is there any association between retroperitoneal lymphadenectomy and survival benefit in advanced stage epithelial ovarian carcinoma patients?

腹膜后淋巴结清扫术与晚期上皮性卵巢癌患者的生存获益之间是否存在关联？

• 发表时间: 2012
• 作者: Sakai K; Kajiyama H; Umezu T; Shibata K; Mizuno M; Suzuki S; Kawai M; Nagasaka T; Kikkawa F.
• 通讯作者: Kikkawa F.

Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles.

评估卵泡液胰岛素、瘦素和脂联素在辅助生殖周期中的预测价值。

• 发表时间: 2010
• 影响因子: 2
• 作者: Takikawa S; Iwase A; Goto M; Harata T; Umezu T; Nakahara T; Kobayashi H;Suzuki K; Manabe S; Kikkawa F.
• 通讯作者: Kikkawa F.

Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement.

Twist 的表达会增加伴有淋巴管间隙受累的 Ib 至 II 期宫颈癌患者肿瘤学结果不佳的风险。

• 发表时间: 2013
• 作者: Kajiyama H; Shibata K; Umezu T; Mizuno M; Suzuki S; Yamamoto E; Fujiwara S; Kikkawa F.
• 通讯作者: Kikkawa F.

Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination

腹膜间皮细胞与卵巢卵黄囊肿瘤干细胞（SC-OYST）在腹膜播散中的功能相互作用

• 发表时间: 2012
• 影响因子: 4.7
• 作者: Mitsui H; Shibata K; Suzuki S; Umezu T; Mizuno M; Kajiyama H; Kikkawa F
• 通讯作者: Kikkawa F