Creation of atopic dermatitis model mouse using double knock out mouse

利用双基因敲除小鼠建立特应性皮炎模型小鼠

• 批准号: 22591240
• 负责人: YONEDA Kozo
• 金额: $ 3.33万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591240/
• 关键词: ロリクリン; ノックアウトマウス; 魚鱗癬; アトピー性皮膚炎; バリア; フレーキーテールマウス; フィラグリン

Atopic dermatitis is one of intractable skin diseases. The clinical feature of this disease is itchy eczema. This disease is caused by mutations in filaggrin gene now. Loricrin is major constituent of marginal band of epidermal corneocyte. The clinical aspects of the variant form of Vohwinkel syndrome are mutilating keratoderma with ichthyosis. This phenotype is similar to ichthyosis vulgaris. Ichthyosis vulgaris is caused by homozygous or compound heterozygous mutations in the filaggrin gene. The aim of this project is creation of atopic dermatitis mouse model using loricrin knock out mouse.

特应性皮炎是顽固性皮肤病之一。本病的临床特点是瘙痒性湿疹。目前这种疾病是由丝聚蛋白基因突变引起的。 Loricrin是表皮角质细胞边缘带的主要成分。 Vohwinkel 综合征变异型的临床表现是伴有鱼鳞病的致残性角皮病。这种表型与寻常鱼鳞病相似。寻常鱼鳞病是由聚丝蛋白基因纯合或复合杂合突变引起的。该项目的目的是使用 loricrin 敲除小鼠创建特应性皮炎小鼠模型。

项目成果

Paraneoplastic pemphigus mimicking toxic epidermal necrolysis associated with B-cell lymphoma

副肿瘤性天疱疮类似于与 B 细胞淋巴瘤相关的中毒性表皮坏死松解症

• 发表时间: 2013
• 影响因子: 3.1
• 作者: Yamada T; Nakamura S; Demitsu T; Nakamura T; Iida E; Yoneda K; Fukuda S;Hashimoto T
• 通讯作者: Hashimoto T

Two cases of nevus sebaceous accompanying secondary tumors with Klothov expression

皮脂腺痣伴发Klothov表达继发性肿瘤2例

• DOI: 10.1111/1346-8138.12371
• 发表时间: 2014
• 影响因子: 3.1
• 作者: Nakai K; Yoneda K; Haba R; Kushida Y; Katsuki N; Moriue J; Moriue T; Ishikawa E; Inoue S;Kubota Y
• 通讯作者: Kubota Y

Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.

片尾小鼠皮肤中表皮生长因子受体、E-钙粘蛋白和闭合蛋白表达的减少是由于聚丝蛋白和兜蛋白缺陷所致。

• DOI: 10.1016/j.ajpath.2012.06.005
• 发表时间: 2012
• 影响因子: 6
• 作者: Nakai K

Numerous mucin nodules in a patient with seropositive wide spread discoid lupus erythematosus

血清反应阳性广泛盘状红斑狼疮患者体内出现大量粘蛋白结节

• 发表时间: 2012
• 影响因子: 1.6
• 作者: Yoneda K; Moriue J; Nakai K; Demitsu T; Moriue T; Yokoi I; Munehiro A; Dobashi H;Kubota Y
• 通讯作者: Kubota Y

Abnormally aggregated caveolin-1 in the cytoplasm of cellular model of classic Vohwinkel syndrome

经典 Vohwinkel 综合征细胞模型细胞质中异常聚集的 Caveolin-1

• 发表时间: 2010
• 作者: Yoneda K; Nakai K; Moriue T; Demitsu T;Kubota Y
• 通讯作者: Kubota Y