Neuromodulation of affective valence in humans by amygdala stimulation

通过杏仁核刺激对人类情感效价的神经调节

• 批准号: 10427427
• 负责人: Krzysztof Bujarski
• 金额: $ 19.48万
• 依托单位: DARTMOUTH-HITCHCOCK CLINIC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427427
• 关键词: Affect; Affective; Amygdaloid structure; Arousal; Behavior; Brain; Cell Nucleus; Clinical Trials; Cognition; Data; Deep Brain Stimulation; Development; Electric Stimulation; Electrodes; Electroencephalography; Emotional; Epilepsy; Event; Foundations; Functional Imaging; Functional disorder; Future; Goals; Human; Hyperactivity; Image; Insula of Reil; Intervention; Judgment; Knowledge; Measures; Mental disorders; Methods; National Institute of Mental Health; Negative Valence; Outcome; Pathologic; Patients; Perception; Performance; Persons; Pharmacologic Substance; Play; Positive Valence; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Property; Psychotherapy; Research; Research Domain Criteria; Role; Techniques; Testing; Therapeutic; Transcranial magnetic stimulation; base; burden of illness; cingulate gyrus; disability-adjusted life years; effective intervention; improved; improved functioning; innovation; neural circuit; neural network; neuroregulation; novel; prefrontal lobe; relating to nervous system; side effect; standard care; years of life lost

PROJECT SUMMARY: Neuromodulation of affective valence in humans by amygdala stimulation Studies investigating global burden of disease have shown that a significant proportion of all disability- adjusted life years are lost due to uncontrolled mental health disorders. For patients with mental illness who have not benefited from conventional psychiatric interventions, neuromodulation via deep brain stimulation (DBS) is an emerging treatment option. Multiple lines of evidence show that dysfunction of the human amygdala plays a pivotal role in the pathophysiology of many psychiatric disorders The long- term goal is to determine if the human amygdala can be a suitable DBS target to treat psychiatric disorders. The main objective for this application is to take advantage of opportunity in patients who have intracranial electrodes for epilepsy to investigate how the amygdala processes affective valence and to determine if electrical stimulation targeted to the basolateral nucleus of the amygdala can be safely used to induce a change in neural network for valence perception and on judgment of affective valence. Our central hypothesis is that electrical stimulation of the basolateral nucleus of the amygdala during performance of an affective valence perception task will change the oscillatory properties of the valence network and in turn change how patients perceive affective valence in pictures without causing the undesirable side effects of stimulation. We propose that the induction of this effect on cognition will have future implications for the treatment of specific psychiatric disorders that are known to involve the amygdala. The central hypothesis will be tested by pursuing two specific aims: (1) Characterize oscillations of the valence network during judgment of valence; (2A) measure the effect of stimulation of the basolateral nucleus of the amygdala on the oscillatory properties of the valence network; and (2B) measure the effect of basolateral nucleus of the amygdala stimulation on perception of affective valence. For Aim 1, we record and analyze intracranial EEG during perception of the Judgment of Valence and Arousal Task to gain better understanding of the oscillatory markers of affective valence. For the Aim 2A, we will use inhibitory stimulation parameters and intracranial EEG to understand how stimulation of the basolateral nucleus of the amygdala affects the oscillatory properties of neural networks for representation of valence. For Aim 2B, we will determine how stimulation affects perception and judgment of valence. The research is innovative because it uses intracranial EEG to gain understanding of neural representation of valence and how stimulation effects neural networks and behavior. The proposed research is significant because it will improve our understanding of neural representation of valence and effect of stimulation parameters on neural network. The research will provide a strong foundation for future development of amygdala DBS for the treatment of specific psychiatric disorders.

项目摘要：通过杏仁核刺激对人类情感价的神经调节 研究全球疾病负担的研究表明，所有残疾的一部分 由于心理健康障碍不受控制，调整后的生活年会丢失。对于精神疾病的患者 他们没有从传统的精神病干预中受益，通过深脑的神经调节 刺激（DBS）是一种新兴治疗选择。多行证据表明 人类杏仁核在许多精神疾病的病理生理学中起关键作用 术语目标是确定人类杏仁核是否可以成为治疗精神病的合适目标 疾病。该应用程序的主要目的是利用机会 具有用于癫痫的颅内电极，以研究杏仁核如何情感价值 并确定是否可以安全地针对杏仁核的基底外侧核的电刺激 用于引起神经网络的变化，以进行价值感知和情感价值的判断。 我们的中心假设是在杏仁核的基底外侧核的电刺激 情感价感知任务的性能将改变价值的振荡特性 网络和反过来改变了患者如何在图片中感知情感价，而不会导致 刺激的不良副作用。我们建议诱导这种对认知的影响 对治疗特定精神疾病的未来影响，已知涉及 杏仁核。中心假设将通过追求两个具体目标来检验：（1）表征 判断价判断期间价网络的振荡； （2a）测量刺激的影响 杏仁核的基底外侧核在价网络的振荡特性上；和（2b） 测量杏仁核刺激的基底外侧核对情感价感知的影响。 对于AIM 1，我们记录和分析颅内脑电图在感知价和价的判断和 唤醒任务以更好地了解情感价的振荡标记。目的 2a，我们将使用抑制性刺激参数和颅内脑电图来了解如何刺激 杏仁核的基底外侧核影响神经网络的振荡特性 价代表。对于AIM 2B，我们将确定刺激如何影响感知和判断力 价。该研究具有创新性，因为它使用颅内脑电图来了解神经 价值的表示以及刺激如何影响神经网络和行为。提议 研究之所以重要，是因为它将提高我们对价值的神经表示的理解和 刺激参数对神经网络的影响。该研究将为 杏仁核DBS的未来开发用于治疗特定的精神疾病。

项目成果

Modulation of Emotion Perception via Amygdala Stimulation in Humans.

• DOI: 10.3389/fnins.2021.795318
• 发表时间: 2021
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Bujarski KA;Song Y;Xie T;Leeds Z;Kolankiewicz SI;Wozniak GH;Guillory S;Aronson JP;Chang L;Jobst BC
• 通讯作者: Jobst BC