Homing of osteogenic progenitors to site of new bone formation in artificial bone substitute

人工骨替代物中成骨祖细胞归巢至新骨形成位点

• 批准号: 21791406
• 负责人: KUMAGAI Ken
• 金额: $ 2.25万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791406/
• 关键词: 人工骨; 骨形成; 末梢血由来細胞; ホーミング; 骨前駆細胞; 骨再生

This study demonstrated that bone formation was stimulated by the addition of bone marrow cells to subcutaneously implanted porous β-TCP blocks in mouse. The data also suggested that recipient derived osteogenic cells migrate into the ceramic pores and contribute to new bone formation. A possible source of osteogenic cells is cells adjacent to local site or circulating osteogenic cells.

这项研究表明，将骨髓细胞添加到小鼠皮下植入的多孔 β-TCP 块中可以刺激骨形成。数据还表明，受体来源的成骨细胞迁移到陶瓷孔中，有助于新骨的形成。成骨细胞是邻近局部部位的细胞或循环成骨细胞。

项目成果

Recruitment of recipient derived osteogenic connective tissue progenitors to β- tricalcium phosphate scaffold combined with bone marrow cells.

将受体来源的成骨结缔组织祖细胞募集到与骨髓细胞结合的β-磷酸三钙支架上。

• 发表时间: 2010
• 作者: 熊谷研

Bone formation and homing of circulating connective tissue progenitors at fracture site were enhanced by low-intensity pulsed ultrasound.

低强度脉冲超声增强了骨折部位的骨形成和循环结缔组织祖细胞的归巢。

• 发表时间: 2010
• 作者: Kumagai K; Takeuchi R; Ishikawa H; Yamaguchi Y; Fujisawa T; Kuniya T; Takagawa S; Saito T.
• 通讯作者: Saito T.

Recruitment of recipient derived osteogenic connective tissue progenitors to β-tricalcium phosphate scaffold combined with bone marrow cells.

将受体来源的成骨结缔组织祖细胞招募到与骨髓细胞结合的β-磷酸三钙支架上。

• 发表时间: 2010
• 作者: Kumagai K; Takeuchi R; Ishikawa H; Saito I; Yamaguchi Y; Chiba N; Takagawa S; Saito T.
• 通讯作者: Saito T.

Effects of Low-Intensity Pulsed Ultrasound on Intramedullary Bone Formation and Homing of Circulating Connective Tissue Progenitors in Fracture with Periosteal Stripping.

低强度脉冲超声对骨膜剥离骨折中髓内骨形成和循环结缔组织祖细胞归巢的影响。

• 发表时间: 2009
• 作者: Kumagai K; Takeuchi R; Ishikawa H; Saito I; Yamaguchi Y; Chiba N; Takagawa S; Saito T.
• 通讯作者: Saito T.

内側型変形性膝関節症に対する高位脛骨骨切り術-内側楔状開大型骨切り術-.OS Now Instruction 16膝・足関節および足趾の骨切り術

胫骨高位截骨术治疗膝关节内侧骨关节炎 - 内侧楔形开放大截骨术 -.OS Now 说明 16 膝关节、踝关节和脚趾截骨术

• 发表时间: 2010
• 作者: 熊谷研; 齋藤知行
• 通讯作者: 齋藤知行