Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases

开发吸入性可生物降解的纳米/微粒，掺入免疫调节 DNA，用于治疗炎症性肺部疾病

• 批准号: 21790778
• 负责人: SATO Takashi
• 金额: $ 2.75万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790778/
• 关键词: 免疫調節性DNA; ナノ粒子

Recently we have developed biomaterials incorporated oligodeoxynucleotide (ODN) achieving acceleration of epithelial cell repair. In this regard, we focused on the effective delivery of ODN to pulmonary immune cells such as alveolar macrophages and bronchial associated lymphoid tissue. Finally, we synthesized biodegradable polyketal nano-particles containing ODN, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the local administrative inhaled approach in lung inflammation study.

最近，我们开发了掺有寡脱氧核苷酸（ODN）的生物材料，可加速上皮细胞修复。在这方面，我们重点关注如何将 ODN 有效递送至肺泡巨噬细胞和支气管相关淋巴组织等肺部免疫细胞。最后，我们合成了含有ODN的可生物降解的聚缩酮纳米粒子，其在酸性条件下表现出持续水解且优选降解。因此，我们可以将我们的研究扩展到肺部炎症研究中的局部吸入方法。

项目成果

CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice.

掺入 CpG 寡脱氧核苷酸的基底膜提取物促进小鼠伤口修复。

• 发表时间: 2009
• 作者: Sato T; Shimosato T; Klinman DM
• 通讯作者: Klinman DM

CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells

嗜热链球菌 lacZ 的 CpG 寡脱氧核苷酸强烈诱导小鼠免疫细胞中白细胞介素 33 的表达

• 发表时间: 2009
• 作者: Shimosato T; Tohno M; Sato T; Tateo M; Otani H; Kitazawa H
• 通讯作者: Kitazawa H

USE OF CpG OLIGODEOXYNUCLE OTIDES TO INDUCE EPITHELIAL CELL GROWTH

使用 CpG 寡脱氧核苷诱导上皮细胞生长

• 发表时间: 2009

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9.

CpG 寡脱氧核苷酸通过 Toll 样受体 9 诱导白细胞介素 33 的强烈上调。

• DOI: 10.1016/j.bbrc.2010.02.110
• 发表时间: 2010-03-26
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: T. Shimosato;Megumi Fujimoto;M. Tohno;Takashi Sato;Mariko Tateo;H. Otani;H. Kitazawa
• 通讯作者: H. Kitazawa

Therapeutic Application and Mechanisms Underlyinng the Activity of Immunosupp ressive Oligonucleotides

免疫抑制寡核苷酸的治疗应用和活性机制

• 发表时间: 2009
• 作者: Klinman DM. Tross D; Klaschik S; Shirota H; Sato T
• 通讯作者: Sato T