Detection of Circulating Endothelial Cells in Severe Sepsis

严重脓毒症中循环内皮细胞的检测

• 批准号: 21390482
• 负责人: KOIKE Kaoru
• 金额: $ 11.65万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390482/
• 关键词: 敗血症; 遊離型血管内皮細胞; CEC; AP-1; TAK-1; NF-κB; 播種性血管愛凝固症候群; DIC; 血管内皮細胞; アポトーシス; ショック; 遺伝子核酸治療; マウス; Death受容体

Sepsis is a severe disorder as systemic inflammation with infection. In this illness, vascular endothelial damage proceeds to induce disseminated intravascular coagulation(DIC). This study revealed that circulating endothelial cell(CEC) was increased and plasma platelet count was decreased in the time dependent manner after sepsis induction by cecal ligation and puncture in male BALB-C mice. Nuclear factor-kappaB decoy oligonucleotides more strongly decreased CEC count than inactivation of FADD, TAK-1, and activator protein-1. The CEC count could be a reliable marker to evaluate DIC and dysfunction of vascular endothelium.

脓毒症是一种严重的疾病，表现为感染引起的全身炎症。在这种疾病中，血管内皮损伤会引发弥散性血管内凝血（DIC）。本研究表明，雄性BALB-C小鼠盲肠结扎和穿刺诱导脓毒症后，循环内皮细胞（CEC）增加，血浆血小板计数呈时间依赖性下降。核因子-kappaB 诱饵寡核苷酸比 FADD、TAK-1 和激活蛋白 1 的失活更能显着降低 CEC 计数。 CEC计数可以作为评估DIC和血管内皮功能障碍的可靠标志物。

项目成果

Up-regulation of histamine H4receptors contributes to splenicapoptosis in septic mice

组胺 H4 受体上调导致脓毒症小鼠脾细胞凋亡

• 发表时间: 2010
• 影响因子: 3.5
• 作者: Matsuda N; Teramae H; Futatsugi M; Takano K; Yamamoto S; Tomita K; SuzukiT; Yokoo H; Koike K; Hattori Y
• 通讯作者: Hattori Y

Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

瑞香素上调 CD38 通过抑制 MAPK/NF-κB/NLRP3 通路减轻脂多糖诱导的肺损伤

• DOI: 10.1186/s12964-023-01041-3
• 发表时间: 2023-03-30
• 期刊: Cell Communication and Signaling : CCS
• 影响因子: 8.4
• 作者: Guo, Yujie;Zhang, Huiqing;Lv, Zhe;Du, Yuna;Li, Dan;Fang, Hui;You, Jing;Yu, Lijun;Li, Rong
• 通讯作者: Li, Rong