Imaging diagnosis of multi-step hepatocarcinogenesis : clinical and basic analysis

多步肝癌的影像诊断：临床与基础分析

• 批准号: 21591549
• 负责人: MATSUI Osamu
• 金额: $ 3万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591549/
• 关键词: 肝細胞癌; 肝癌多段階発癌; Gd-EOB-DTPA造影MRI; 早期肝癌; 悪性度; 信号強度; AFP; PIVKA-II; Gd-EOB-DTPA; dysplastic nodule; MRI; トランスポーター; OATP8; MRP3

In accordance with the progression of multi-step hepatocarcinogenesis, the drainage vessels from the tumor changed from hepatic vein to hepatic sinusoids, and then portal vein, and this can be diagnosed by dynamic CT. There was an intensely significant correlation between OATP8 expression and signal intensity on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI. In addition, the expression of OATP8 was decreased from very early stage of hepatocarcinogenesis in accordance with the elevation of grade of malignancy of the tumors. Therefore, EOB-MRI was proved to be extremely useful in the diagnosis of early HCC

根据肝癌的多步进展，肿瘤的引流血管由肝静脉变为肝窦，再到门静脉，动态CT可诊断。 OATP8 表达与 Gd-EOB-DTPA 增强 MRI 肝胆期信号强度之间存在极显着相关性。此外，OATP8的表达从肝癌发生的极早期开始就随着肿瘤恶性程度的升高而降低。因此，EOB-MRI被证明对早期HCC的诊断非常有用

项目成果

Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography--radiologic-pathologic correlation.

肝癌发生：动脉门静脉造影和肝动脉造影期间 CT 引流血管的多步变化 - 放射学 - 病理学相关性。

• DOI: 10.1148/radiol.2522081414
• 发表时间: 2009-08-01
• 期刊: Radiology
• 影响因子: 19.7
• 作者: A. Kitao;Y. Zen;O. Matsui;T. Gabata;Y. Nakanuma
• 通讯作者: Y. Nakanuma

Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities

伴有各种先天性和获得性肝血流动力学异常的肝细胞结节性病变的放射学和组织病理学表现

• 发表时间: 2009
• 作者: Kobayashi S; Matsui O; Gabata T; et al
• 通讯作者: et al

肝細胞癌の多段階発癌における肝細胞膜トランスポーターOATP8の発現変化:Gd-EOB-DTPA造影MRIとの対比

肝细胞癌多步癌变过程中肝细胞膜转运蛋白OATP8表达的变化：与Gd-EOB-DTPA增强MRI的比较

• 发表时间: 2011
• 作者: 松井修;北尾梓;小坂一斗;有井滋樹
• 通讯作者: 有井滋樹

Cirrhotic rat liver: reference to transporter activity and morphologic changes in bile canaliculi--gadoxetic acid-enhanced MR imaging.

肝硬化大鼠肝脏：参考胆小管转运蛋白活性和形态变化——钆塞酸增强磁共振成像。

• DOI: 10.1148/radiol.10092065
• 发表时间: 2010-09-01
• 期刊: Radiology
• 影响因子: 19.7
• 作者: N. Tsuda;O. Matsui
• 通讯作者: O. Matsui

Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade

肝胆期造影剂摄取的量化有助于区分肝细胞癌级别

• DOI: 10.1038/s41598-021-02499-2
• 发表时间: 2021-11-26
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: Haimerl M;Utpatel K;Götz A;Zeman F;Fellner C;Nickel D;Luerken L;Brennfleck F;Stroszczynski C;Scheiter A;Verloh N
• 通讯作者: Verloh N