Experimental study on the transcatheter proximal arterial occlusion maintaining the blood supply to the distal organs.

经导管近端动脉闭塞维持远端器官血供的实验研究。

• 批准号: 02807102
• 负责人: MATSUI Osamu
• 金额: $ 0.96万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807102/
• 关键词: arterial bleeding; gastrointestinal bleeding; transcatheter arterial occlusion; balloon catheter; autoperfusion; artificial blood; interventional angiography; autopertusion; イエ血液; inter vention al angiography; 経カテ-テル的動脈塞栓術; INTERVENTIONAL AN GI

(1)Experimental study on the usefulness of the autoperfusion balloon catheter in maintaining the blood supply to the distal organs :a)We circulated glycerin solution by means of the vessel model and the pump for dialysis, and we measured the amount of the solution passing through the sideholes per a minute. As a result. it can be concluded that APBCs with 3-5 sideholes of 0.8-1.3sm in diameter are most suitable for APBC, because these can pass sufficient amount of glycerin solution and can be flushed effectively and do not kink. The amount of glycerin solution which pass through 7F. APBC with 3 sideholes of 1.3mm in diameter was 129ml/minute.b)Following the previous year, - we inserted APBCs into the superior mesenteric arteries of the dogs and tried to investigate peripheral arterial flow through the proximal sideholes. But APBC was occluded by thrombi in relatively short periods. So we thought that superior mesenteric artery is not suitable for our experimental study.c)Autoperfusion … More balloon catheters(APBC)were inserted into the renal arteries of seven dogs for about two and a half hours. Abdominal aortography showed renal arterial flow of the kidney obstructed by APBC. Macroscopic and microscopic examination revealed no significant changes in the resected specimen. It is concluded that APBC is useful in cases of the proximal arterial occlusion by maintaining the blood supply to the distal organs for relatively short periods and that it can be used for the treatment of rupture of arteries which feed critical organs.(2)Experimental study on the efficacy of oxygenated artificial blood :We occluded renal arteries of five dogs by ordinary balloon catheter, and injected oxygenated artificial blood(perfluorochemical emulsion)at various speed for two hours by injector. Then we sacrified them and examined the occluded kidney macroscopically and microscopically. The result was that when we injected perfluorochemical emulsion at such a speed as more than 20ml/hour/kg. no significant changes could be revealed on macroscopic and microscopic examination. This injection speed was thought to be the lowest speed which was necessary for the proximal arterial occlusion which can maintain the oxygen supply to the distal organs by perfluorochemical emulsion. Less

(1)自灌注球囊导管维持远端器官血液供应的实验研究：a)通过血管模型和透析泵回收甘油溶液，并测量通过的溶液量由此可以得出，具有3-5个直径为0.8-1.3sm的侧孔的APBC最适合，因为它们可以通过足够量的气体。甘油溶液，可有效冲洗且不扭结。通过具有3个直径为1.3mm的侧孔的7F的甘油溶液的量为129ml/分钟。b)继去年之后，-我们将APBC插入上级。狗的肠系膜动脉并试图研究通过近端侧孔的外周动脉血流，但 APBC 在相对较短的时间内被血栓闭塞。因此我们认为肠系膜上动脉不适合我们的实验研究。c）将自体灌注球囊导管（APBC）插入七只狗的肾动脉约两个半小时，腹主动脉造影显示肾动脉血流。宏观和显微镜检查显示切除的标本没有明显变化，结论是 APBC 通过维持血液供应在近端动脉闭塞的情况下是有用的。 (2)含氧人工血功效的实验研究：用普通球囊导管闭塞5只狗的肾动脉，并用注射器以不同的速度注射含氧人造血（全氟化学乳剂）两个小时，然后将其处死，并对闭塞的肾脏进行宏观和微观检查。以超过20ml/小时/kg的速度注射全氟化合物乳液，在宏观和微观检查中均未发现明显变化，该注射速度被认为是维持近端动脉闭塞所需的最低速度。全氟乳剂对远端器官的供氧量较少。