Common pathological background of chronic kidney disease and life-habit associated metabolic disorders
慢性肾脏病和生活习惯相关代谢紊乱的常见病理背景
基本信息
- 批准号:20590941
- 负责人:
- 金额:$ 2万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Chronic kidney disease (CKD) and life-style related metabolic disorders such as hypertension, and diabetes, are independent risk factors for excess cardiovascular events, however the common pathological mechanisms or causative molecules have remained to be addressed. The present study identified glucose degraded molecule ? methylglyoxal as one of the candidates. Methylglyoxal induces cellular and organ damage by enhancing oxidative stress. Furthermore, it was suggested that the degraded process of methylglyoxal may facilitate purine metabolism, leading to uric acid production.
慢性肾病(CKD)和生活方式相关的代谢性疾病(如高血压和糖尿病)是心血管事件过多的独立危险因素,但常见的病理机制或致病分子仍有待解决。本研究确定了葡萄糖降解分子?甲基乙二醛为候选者之一。甲基乙二醛通过增强氧化应激诱导细胞和器官损伤。此外,有人认为甲基乙二醛的降解过程可能促进嘌呤代谢,导致尿酸产生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biological Effect of Electrolyzed Water on Human Neutrophils and Clinical Application to Hemodialysis Treatment.
电解水对人体中性粒细胞的生物学效应及其在血液透析治疗中的临床应用。
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Nakayama M; et al.
- 通讯作者:et al.
A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis : a clinical trial
一种利用水电解产生的溶解氢气(H2)的新型生物活性血液透析系统:临床试验
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Nakayama M; et al.
- 通讯作者:et al.
Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells
甲基乙二醛增强人主动脉内皮细胞的细胞内氧化应激
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Miyazawa N; Abe M; Souma T; Tanemoto M; Abe T; Nakayama M; Ito S
- 通讯作者:Ito S
Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells
甲基乙二醛增强人主动脉内皮细胞的细胞内氧化应激
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Miyazawa N; et al.
- 通讯作者:et al.
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NAKAYAMA Masaaki其他文献
NAKAYAMA Masaaki的其他文献
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{{ truncateString('NAKAYAMA Masaaki', 18)}}的其他基金
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开发利用分子氢的创新腹膜透析系统
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23591196 - 财政年份:2011
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Control of optical responses of exciton-stable materials by microstructures
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22340084 - 财政年份:2010
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$ 2万 - 项目类别:
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Generation mechanism of terahertz electromagnetic waves in semiconductor quantum structures
半导体量子结构中太赫兹电磁波的产生机制
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18340090 - 财政年份:2006
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$ 2万 - 项目类别:
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Control of coherent phonons with excitonic quantum beats
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15340102 - 财政年份:2003
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$ 2万 - 项目类别:
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Control of photoexcited-carrier distribution through intersubband resonances in semiconductor superlattices
通过半导体超晶格中的子带间共振控制光激发载流子分布
- 批准号:
11640322 - 财政年份:1999
- 资助金额:
$ 2万 - 项目类别:
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High-density-excitation states in GaAs/AlAs type-II superlattices
GaAs/AlAs II 型超晶格中的高密度激发态
- 批准号:
09640404 - 财政年份:1997
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$ 2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Miniband structures in semiconductor superlattices investigated by modulated-reflectance spectroscopy
通过调制反射光谱研究半导体超晶格中的微带结构
- 批准号:
07640450 - 财政年份:1995
- 资助金额:
$ 2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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