Mechanisms in epithelial-mesenchymal transition in chronic obstructive pulmonary disease

慢性阻塞性肺疾病上皮间质转化的机制

• 批准号: 20590896
• 负责人: ITO Isao
• 金额: $ 3.08万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590896/
• 关键词: II型肺胞上皮細胞; サーファクタントプロテインC; 上皮間葉移行; COPD; 気管支喘息; 気道上皮細胞; 慢性閉塞性肺疾患; 末梢気道

By adding appropriate concentration of TGF-β to cultured BEAS-2B cell, the cells exhibited epithelial-mesenchymal transition, which were enhanced by addint TLR-ligands. To perform further experiments on EMT, induced pluripotent stem cells were established from patients with COPD and inducing type II pneumocytes from iPS cells is being tried.

通过向培养的 BEAS-2B 细胞中添加适当浓度的 TGF-β，细胞表现出上皮-间质转化，并通过添加 TLR-配体来增强这种转化。正在尝试从 iPS 细胞诱导 II 型肺细胞。

项目成果

Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration : comparison with imipenem/cilastatin.

他佐巴坦/哌拉西林治疗有误吸风险的中重度肺炎患者：与亚胺培南/西司他丁比较。

• 发表时间: 2010
• 作者: Ito I; Kadowaki S; Tanabe N; Haruna A; Kase M; Yasutomo Y; Tsukino M; Nakai A; Matsumoto H; Niimi A; Chin K; Ichiyama S; Mishima M.
• 通讯作者: Mishima M.

PDGF and TGF-b modulate expression of MMPs and migratory function in human airway smooth muscle cells

PDGF和TGF-b调节人气道平滑肌细胞中MMP的表达和迁移功能

• 作者: Isao Ito

黄砂飛来時の小児喘息入院リスク上昇は花粉予報時に低減:富山でのCase-Crossover Study

花粉预报期间黄尘期间儿童哮喘住院风险增加：富山病例交叉研究

• 发表时间: 2010
• 作者: 金谷久美子

TNF-αによるヒト気道平滑筋細胞MMP発現と細胞遊走への影響

TNF-α对人气道平滑肌细胞MMP表达及细胞迁移的影响

• 发表时间: 2008
• 作者: 伊藤功朗; ら
• 通讯作者: ら

Association of alveolar nitric oxide levels with pulmonary function and its reversibility in stable asthma.

肺泡一氧化氮水平与肺功能的关联及其在稳定哮喘中的可逆性。

• 发表时间: 2010
• 作者: Matsumoto H; Niimi A; Jinnai M; Nakaji H; Takeda T; Oguma T; Otsuka K; Inoue H; Yamaguchi M; Matsuoka H; Ito I; Hirai T; Chin K; Mishima M.
• 通讯作者: Mishima M.