Synthesis of novel periodic copolymers with a function inducing biodegradability as responsive to outer stimulus

具有响应外部刺激而诱导生物降解功能的新型周期性共聚物的合成

• 批准号: 20350072
• 负责人: ABE Hideki
• 金额: $ 10.23万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20350072/
• 关键词: 周期性共重合体; 連鎖構造制御; 生分解性; 3-ヒドロキシブタン酸; スイッチ機能; 重縮合; イオンコンプレックス; 周期共重合体; 酵素分解; 側鎖長効果; 分子鎖末端活性化処

Synthesis of copolymers with periodic sequence structure was achieved by two-step polycondensation reaction from 3-hydroxybutyrate and aspartate. When the copolymers reacted with alkyl amine to form ion-complex at side-chain of aspartate units, the enzymatic degradation reaction by polyester-degrading enzyme was inhibited. It was found that the enzymatic degradability of copolymers was regained by the washing under the acidc condition. From the obtained results, we proposed new methodology to control the starting point of biodegradation for the periodic copolymers by changing the pH as outer stimulus.

以3-羟基丁酸酯和天冬氨酸为原料，通过两步缩聚反应合成了具有周期序列结构的共聚物。当共聚物与烷基胺反应在天冬氨酸单元侧链形成离子络合物时，聚酯降解酶的酶促降解反应受到抑制。结果发现，在酸性条件下洗涤后，共聚物的酶降解性得以恢复。根据所获得的结果，我们提出了通过改变 pH 作为外部刺激来控制周期性共聚物生物降解起点的新方法。

项目成果

Syntheses and characterization of novel periodic copoly(ester-amide)s derived from renewable resources

可再生资源新型周期性共聚（酯-酰胺）的合成和表征

• 发表时间: 2008
• 作者: 阿部英喜

Chemosynthesis and function of 3-hydroxybutyrate-based periodic copolymers

3-羟基丁酸酯基周期共聚物的化学合成及功能

• 发表时间: 2010
• 作者: 阿部英喜

Chemical synthesis and functionalization of 3-hydroxybutyrate-based copolymers with periodic sequence structure

具有周期序列结构的3-羟基丁酸酯共聚物的化学合成及功能化

• 发表时间: 2009
• 作者: 阿部英喜

Syntheses and characterization of novel periodic copoly(ester-amide) s derived from renewable resources

可再生资源新型周期性共聚（酯-酰胺）的合成和表征

• 发表时间: 2008
• 作者: Hideki Abe

周期配列バイオポリマーの合成、物性、生分解性に関する研究

周期性阵列生物聚合物的合成、物理性质及生物降解性研究

• 发表时间: 2010
• 作者: 阿部英喜