The gene therapy for sepsis by the clarification of STAT3 / SOCS3 which control an inflammatory or an anti-inflammatory reaction

通过阐明控制炎症或抗炎反应的 STAT3 / SOCS3 进行败血症的基因治疗

• 批准号: 25462809
• 负责人: Sawamura Atsushi
• 金额: $ 3.16万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462809/
• 关键词: 敗血症病態; サイトカイン; IL-6; TNF-αKO; 遺伝子治療; Western Blotting; 敗血症脳症; TNF-α; 外傷; 敗血症; DIC; 臓器不全

项目成果

Increased thrombin activation and lower antithrombin levels in patients with DIC and acute coagulopathy of trauma-shock(ACOTS)

DIC 和创伤休克急性凝血病 (ACOTS) 患者凝血酶活性增加和抗凝血酶水平降低

• 发表时间: 2013
• 作者: Gando S;Yanagida Y;Sawamura A;Hayakawa M;Kubota N;Ono Y;Wada T;Yamamoto H
• 通讯作者: Yamamoto H

DIC and fibrinolysis in patients with trauma and out-of-hospital cardiac arbest.

外伤和院外心脏骤停患者的 DIC 和纤溶。

• 发表时间: 2016
• 作者: Gando S;Wada T;Ono Y;Maekawa K;Katabami K;Hayakawa M;Sawamura A.
• 通讯作者: Sawamura A.

Impaired coagulation mechanisms in trauma patients with disseminated intravascular coagulation and acute coagulopathy trauma-shock.

患有弥散性血管内凝血和急性凝血病创伤休克的创伤患者的凝血机制受损。

• 发表时间: 2015
• 作者: 久志本成樹;工藤大介;吉田良太朗;江頭隆一郎;Gando S;久志本成樹;Wada T, 他6名;Gando S
• 通讯作者: Gando S

JAAM DIC score can predict patient death and massive transfusion in trauma.

JAAM DIC 评分可以预测患者死亡和创伤中的大量输血。

• 发表时间: 2014
• 作者: Sakuramoto H;Shimojo N;Jesmin S;Unoki T;Kamiyama J;Oki M;Miya K;Kawano S;Mizutani T.;Gando S
• 通讯作者: Gando S

Effects of Rikkunshito (traditional Japanese Kampo) on enteral feeding and plasma ghrelin concentration in critically ill patients: A double-blind, randomized, controlled trial.

Rikkunshito（传统日本汉方）对危重患者肠内喂养和血浆生长素释放肽浓度的影响：一项双盲、随机、对照试验。

• 发表时间: 2013
• 作者: Hayakawa M;Yamamoto H;Ono Y;Wada T;Yanagida Y;Sugano M;Sawamura A;Takeda H;Gando S
• 通讯作者: Gando S