The roles of nuclear IkappaB protein in the regulation of B cell function

核IkappaB蛋白在B细胞功能调节中的作用

• 批准号: 24790466
• 负责人: TOUMA Maki
• 金额: $ 2.66万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790466/
• 关键词: リンパ球; 転写因子; B細胞; NF-κB; Toll様受容体(TLR); IκB; 抗体産生

A transcription factor nuclear factor-kappaB (NF-kappaB) plays an essential role in the overall regulation of the immune system and inflammatory responses. Activation of NF-kappaB is tightly regulated by inhibitory proteins termed IkappaB, which consist of classical cytoplasmic and nuclear IkappaBs. Roles of a nuclear regulator of NF-kappaB, IkappaBNS, in the development and function of B cells were studied. We have found that IkappaBNS is important for proliferative activity and antibody production via Toll-like receptor signals. IkappaBNS is also involved in the development of regulatory B cells that produce anti-inflammatory cytokine IL-10. Thus, an additional important role for IkappaBNS in control of the immune response was defined.

转录因子核因子 - 卡帕布（NF-kappab）在免疫系统和炎症反应的总体调节中起着至关重要的作用。 NF-kappab的激活受到称为iKappab的抑制蛋白的严格调节，这些蛋白质由经典的细胞质和核ikappab组成。研究了NF-kappab，ikappabns的核调节剂在B细胞的开发和功能中的作用。我们发现，Ikappabns对于通过Toll样受体信号的增殖活性和抗体产生很重要。 Ikappabns还参与了产生抗炎细胞因子IL-10的调节B细胞的发展。因此，定义了Ikappabn在控制免疫反应中的另一个重要作用。

项目成果

A dominant trait linked to chromosome 1 in DBA/2 mice for the resistance to autoimmune gastritis appears in bone marrow cells

DBA/2 小鼠的骨髓细胞中出现了与 1 号染色体相关的抵抗自身免疫性胃炎的显性特征

• 发表时间: 2014
• 期刊: Exp Anim
• 作者: Fujii M;Suzuki K;Suenaga S;Wakatsuki M;Kushida Y;Touma M;and Hosono M
• 通讯作者: and Hosono M

The atypical IκB protein IκBNS is important for TLR-induced IL-10 production in B cells

非典型 IκB 蛋白 IκBNS 对于 TLR 诱导 B 细胞产生 IL-10 很重要

• 发表时间: 2013
• 作者: Minami Miura;Mitsuo Noguchi;Maki Touma
• 通讯作者: Maki Touma

A lack of IκBNS leads to impaired function of marginal zone B cells and modulates TLR-induced B cell responses.

IκBNS 缺乏会导致边缘区 B 细胞功能受损并调节 TLR 诱导的 B 细胞反应。

• 发表时间: 2012
• 作者: Maki Touma;Linda K Clayton
• 通讯作者: Linda K Clayton

A key role for the nuclear IκB protein IκBNS in control of B cell development and function

核 IκB 蛋白 IκBNS 在控制 B 细胞发育和功能中的关键作用

• 发表时间: 2012
• 作者: TOUMA Maki;CLAYTON Linda K
• 通讯作者: CLAYTON Linda K

A lack of IkappaBNS leads to impaired function of marginal zone B cells and modulates TLR-induced B cell responses

IkappaBNS 缺乏会导致边缘区 B 细胞功能受损并调节 TLR 诱导的 B 细胞反应

• 发表时间: 2012
• 作者: TOUMA Maki;CLAYTON Linda K
• 通讯作者: CLAYTON Linda K