The mechanism of development of the suprachiasmatic nucleus

视交叉上核的发育机制

• 批准号: 24790288
• 负责人: HATAKEYAMA Jun
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790288/
• 关键词: 視交叉上核; 神経発生; 核形成; Dbx1; 核構造; 発生; 国際研究者交流（フランス）; 国際研究者交流フランス; 神経幹細胞

Every kingdom of life-bacteria, plants, and animal- has 24-hours rhythms. In mammal, the suprachaismatic nucleus (SCN) works as a center of the biological clock and the function is well known. However the mechanism of development of that is poorly understood. I found that homeobox genes, Lhx1 and Dbx1, are expressed by differentiating neurons and neural progenitors of SCN respectively. And Ror-alpha is also expressed by differentiating neurons of SCN. In Dbx1 knockout mice, neurons of SCN which are Ror-alpha positive cells were decreased. This result indicated that Dbx1 is important for the formation of SCN.

生命 - 细菌，植物和动物的每个王国都有24小时的节奏。在哺乳动物中，上核（SCN）是生物钟的中心，并且该功能是众所周知的。但是，发展的机制知之甚少。我发现同型基因LHX1和DBX1分别通过SCN的神经元和神经祖细胞来表达。 Ror-alpha也通过区分SCN的神经元表示。在DBX1基因敲除小鼠中，SCN的神经元是ROR-Alpha阳性细胞的降低。该结果表明DBX1对于SCN的形成很重要。

项目成果

Pace control of neurogenesis regulated by transient retention of the apical endfoot of differentiating cells via Notch signaling

通过Notch信号传导分化细胞顶端足的瞬时保留来调节神经发生的速度控制

• 发表时间: 2014
• 作者: Kenji Shimamura;Jun Hatakeyama;and Haruka Sato-Takemoto
• 通讯作者: and Haruka Sato-Takemoto

生まれたてのニューロンのapical endfootによるNotchシグナルの調節を介した神経分化ペースのコントロール

通过新生神经元顶端足调节Notch信号来控制神经元分化的速度

• 发表时间: 2013
• 作者: Hatakeyama J;Lumsden A;Kageyama R;Shimamura K.;Jun Hatakeyama
• 通讯作者: Jun Hatakeyama

The apical endfoot of nascent neuron controls the pace of neurogenesis through the regulation of notch signaling Neuro2013

新生神经元的顶端足通过调节缺口信号来控制神经发生的速度 Neuro2013

• 发表时间: 2013
• 作者: Jun Hatakeyama;Yoshio Wakamatsu;Ryuichi Shigemoto;Akira Nagafuchi;and Kenji Shimamura
• 通讯作者: and Kenji Shimamura

Regulation of Notch signaling through the adherens junction in neurogenesis and somitogenesis

通过粘附连接调节神经发生和体节发生中的Notch信号传导

• 发表时间: 2012
• 作者: Jun Hatakeyama;Yoshio Wakamatsu;Ryuichi Shigemoto;Kenji Shimamura
• 通讯作者: Kenji Shimamura

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

• DOI: 10.1242/dev.102988
• 发表时间: 2014-04-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Hatakeyama, Jun;Wakamatsu, Yoshio;Shimamura, Kenji
• 通讯作者: Shimamura, Kenji