molecular mechanism underlying intracellular heme transport

细胞内血红素转运的分子机制

• 批准号: 24770121
• 负责人: UETA Ryo
• 金额: $ 3万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770121/
• 关键词: ヘム; 鉄; ミトコンドリア; 出芽酵母

Using S. cerevisiae, we performed the screening for mutants that are defective in intracellular heme trafficking, and isolated one mutant carrying mutation in a transcriptional regulator. In this mutant, the expression of many genes that are involved in respiration and metabolic pathways processed in mitochondria, suggesting that this transcriptional regulator controls not only heme trafficking, but also mitochondria-related metabolism.

使用酿酒酵母，我们对细胞内血红素运输有缺陷的突变体进行了筛选，并在转录调节剂中分离了一个携带突变的突变体。在这个突变体中，在线粒体中处理的许多基因的表达与呼吸和代谢途径有关，这表明该转录调节剂不仅控制血红素的运输，还控制与线粒体相关的代谢。

项目成果

Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters Is an Initial Event in Iron-Dependent Gene Suppression

• DOI: 10.1128/mcb.00726-12
• 发表时间: 2012-12-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Ueta, Ryo;Fujiwara, Naoko;Yamaguchi-Iwai, Yuko
• 通讯作者: Yamaguchi-Iwai, Yuko