Structural study of heme transporter from pathogenic bacteria

病原菌血红素转运蛋白的结构研究

• 批准号: 24770110
• 负责人: NAOE Youichi
• 金额: $ 2.91万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770110/
• 关键词: ヘム; 膜タンパク質; ABCトランスポーター; 結晶; ABC トランスポーター; X 線結晶構造解析

Pathogenic bacteria sequester heme from the infected host as an iron source. Heme transporter is the membrane protein used to transport heme into the cytoplasm. To further understanding of the transport mechanism, I have pursued X-ray crystallographic analysis. Through trial and error, 3.5 Å resolution crystal of heme transporter was obtained. In addition, colored crystal thought to be heme-bound has been obtained.

感染的宿主作为铁源的致病细菌。 Thoutal Thout

项目成果

Crystal structure of novel periplasmic heme binding protein.

新型周质血红素结合蛋白的晶体结构。

• 发表时间: 2012
• 作者: 直江洋一;沢辺美亜;杉本宏;城宜嗣
• 通讯作者: 城宜嗣