Comparative twin study in elderly: Relationship between oral status and environmental status

老年人比较双胞胎研究：口腔状况与环境状况的关系

• 批准号: 24792074
• 负责人: MATSUDA Ken-ichi
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792074/
• 关键词: 高齢双生児; 双生児研究; 環境要因; 遺伝要因

The purpose of this study was to detect the heritability of the individual oral health, including tooth loss, ability of chewing, morphologic figures. Morphologic figures such as length or width of the jaw have genetic predisposition. But, loss of teeth is greatly influenced from environmental factors. And the ability of chewing has both aspects of genetic and environmental factors. These results would be important for both dentists and patients to prevent compromised dental condition, and to recognize the limit of the treatment.Second aim was to assess the relationship between number of remaining teeth and arterial sclerosis considering genetic factors. From our study, there was a genetic contribution to the association of them. And even after eliminating such a genetic confounding, there was a significant association of them. Therefore, tooth loss would be considered as an important environmental factor to affect arterial sclerosis.

这项研究的目的是检测单个口腔健康的遗传力，包括牙齿脱落，咀嚼能力，形态学数字。诸如下颌的长度或宽度之类的形态学数字具有遗传易感性。但是，牙齿的损失受到环境因素的很大影响。咀嚼能力都具有遗传和环境因素的方面。这些结果对于牙医和患者以防止牙齿疾病受损并认识到治疗的极限至关重要。第二个目标是评估考虑遗传因素的剩余牙齿数量与动脉硬化的关系。从我们的研究中，对它们的关联有遗传贡献。即使消除了这种遗传混乱，它们也存在很大的关联。因此，牙齿脱落将被视为影响动脉硬化的重要环境因素。

项目成果

Genetic and environmental influences on oral condition among elder twins

遗传和环境对年长双胞胎口腔状况的影响

• 发表时间: 2013
• 作者: Kurushima Y;Ikebe K;Matsuda K;Enoki K;Ogata S;Yamashita M;Murakami S;Kato K;Hayakawa K;Maeda Y;Osaka Twin Research Group
• 通讯作者: Osaka Twin Research Group

高齢双生児における口腔領域の類似度

老年双胞胎口腔区域的相似性

• 发表时间: 2013
• 作者: Kurushima Y;Ikebe K;Matsuda K;Enoki K;Ogata S;Yamashita M;Murakami S;Kato K;Hayakawa K;Maeda Y;久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信
• 通讯作者: 久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信