Development of functional glyco-devices using fluorous interaction

利用氟相互作用开发功能性糖装置

• 批准号: 19300168
• 负责人: HATANAKA Kenichi
• 金额: $ 11.32万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300168/
• 关键词: 糖鎖; 糖鎖生産; 医用材料; 細胞; フルオラス; 糖鎖認識; 糖鎖プライマー; レクチン; ウイルス; インフルエンザ; GM3; 糖鎖の固定化; プライマー; グリコシル化; 臨界ミセル濃度; 表面張力; 細胞膜; フルオラスタグ

Glyco-compound having fluoroalkyl chain was synthesized and its carbohydrate chain was elongated using cells. The oligosaccharide having fluoroalkyl chain was immobilized on the fluoro-material and the immobilized material was tested for the absorption of influenza virus. It was found that the ethylene oxide oligomer was necessary as a spacer for recognition of influenza virus. It was confirmed that the immobilized oligosaccharide compound having oligo(ethylene oxide) spacer was specifically recognized by influenza virus.

合成了具有氟烷基链的糖化合物，并利用细胞延长了其碳水化合物链。将具有氟代烷基链的寡糖固定在氟材料上，并测试固定材料对流感病毒的吸收。发现环氧乙烷低聚物作为间隔物对于识别流感病毒是必需的。确认了具有寡聚(环氧乙烷)间隔基的固定化寡糖化合物被流感病毒特异性识别。

项目成果

Purification of Gangliosides by liquid-liquid partition chromatography

液-液分配色谱法纯化神经节苷脂

• 发表时间: 2008
• 作者: T.Kato; M.C.Kasuya; K.Hatanaka
• 通讯作者: K.Hatanaka

Effect of lipid mimics of GM3 and lyso-GM3 dimer on EGF receptor tyrosine kinase and EGF-induced signal transduction

GM3和lyso-GM3二聚体的脂质模拟物对EGF受体酪氨酸激酶和EGF诱导的信号转导的影响

• 发表时间: 2008
• 作者: Y.Haga; K.Hatanaka; S.Hakomori
• 通讯作者: S.Hakomori

Incorporation of Fluorous Glycoside in Cell and Oligosaccharide Production

细胞和寡糖生产中掺入氟糖苷

• 发表时间: 2009
• 作者: K.Hatanaka

Quantitative Analysis of EGFR Affinity to Immobilized Glycolipids by Surface Plasmon Resonance

通过表面等离子共振定量分析 EGFR 对固定化糖脂的亲和力

• 发表时间: 2008
• 作者: Y.Haga; S.
• 通讯作者: S.

Inhibitory effects of glycopolymers having globotriose and/or lactose on cytotoxicity of Shiga toxin 1

具有球三糖和/或乳糖的糖聚合物对志贺毒素1的细胞毒性的抑制作用

• DOI: 10.1016/j.carbpol.2006.05.020
• 发表时间: 2007-01-22
• 期刊: Carbohydrate Polymers
• 影响因子: 11.2
• 作者: Atsushi Miyagawa;M. Kasuya;K. Hatanaka
• 通讯作者: K. Hatanaka