Chemical state analysis of rarely contained biological metallic element using X-ray absorption fine structure (XAFS) analysis

使用 X 射线吸收精细结构 (XAFS) 分析对很少含有的生物金属元素进行化学状态分析

• 批准号: 18390509
• 负责人: UO Motohiro
• 金额: $ 11.78万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390509/
• 关键词: XAFS; X線吸収微細構造; 微小部分析; 生体材料; 歯科材料; 金属; 化学状態; チタン; 溶出; 歯科用材料; 歯科理工学; インプラント; ニッケルチタン合金

In this study, the chemical state of metallic elements and micro foreign bodies contained in the biological tissues were analyzed using XAFS method and the behavior of dental and medical alloys (e.g.titanium, nickel-titanium alloy, chromium-based alloy) was evaluated. Titanium in the surrounding tissues of dental and medical implants was usually existed as the metallic Ti, but, the titanium oxide was also detected. The titanium oxide was considered as derived from the dissolved and precipitated Ti. Nickel was existed as the ionic state in the surroundings of nickel-based alloy, then, the toxic effect of Ni ion to the surrounding tissues was concerned. In addition, trace element in the tussues (e.g.Se) analysis and micro XAFS analysis were also carried. In conclusion, the possibility of XAFS analysis for the biological tissue was suggested.

本研究利用XAFS方法分析了生物组织中所含金属元素和微异物的化学状态，并对牙科和医用合金（例如钛、镍钛合金、铬基合金）的行为进行了评估。牙科和医疗植入物周围组织中的钛通常以金属钛的形式存在，但也检测到氧化钛。认为氧化钛源自溶解和沉淀的Ti。镍在镍基合金周围以离子状态存在，因此人们担心镍离子对周围组织的毒性作用。此外，还进行了荨麻中的微量元素（例如Se）分析和显微XAFS分析。总之，提出了对生物组织进行 XAFS 分析的可能性。

项目成果

Preparation and properties of dental composite resin cured under near infrared irradiation

近红外固化牙科复合树脂的制备及性能

• 发表时间: 2009
• 作者: Uo M.; Kudo E.; Okada A.; Soga K.; Kogo Y.
• 通讯作者: Kogo Y.

Chemical state analysis of titanium and nickel in the surrounding tissues of metallic implants

金属植入物周围组织中钛和镍的化学状态分析

• 发表时间: 2007
• 作者: Uo M.. Asakura K.; Watari F.
• 通讯作者: Watari F.

XAFS Analysis of Ti and Ni Dissolution from Pure Ti, Ni-Ti Alloy, and SUS304 in Soft Tissues

XAFS 分析软组织中纯钛、镍钛合金和 SUS304 中钛和镍的溶解

• 发表时间: 2008
• 作者: Uo M.; Asakura K..; Watari F.; 他4名
• 通讯作者: 他4名

Effect of surface condition of dental zirconia ceramic (Denzir) on bonding

牙科氧化锆陶瓷 (Denzir) 表面状况对粘合的影响

• 发表时间: 2006
• 作者: Uo M.; Watari F.; 他4名
• 通讯作者: 他4名

Micro XAFS analysis of metallic element containing biological specimens using the polycapillary focusing X-ray optics

使用多毛细管聚焦 X 射线光学器件对含有金属元素的生物样本进行显微 XAFS 分析

• 发表时间: 2009
• 作者: Uo M.; Asakura K.
• 通讯作者: Asakura K.