Improvement of biocompatibility of metallic biomaterials by surface amorphization

通过表面非晶化改善金属生物材料的生物相容性

• 批准号: 15390581
• 负责人: UO Motohiro
• 金额: $ 9.09万
• 依托单位: Hokkaido Univerisity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390581/
• 关键词: rarely conteined element; biocompatibility; titanium; X-ray absorption fine structure (XAFS); metal; nitrization; セレン; レーザー急冷法; 非晶質; X線回析

The biocompatibility is strongly affected by the physical and chemical properties of materials' surfaces. Metal carbides and nitrides are chemically stable compared to their original metals. Then, their biocompatibility are also same as or better than their original metals.Recently, high energy lasers are applied to the welding of metallic dental restoratives. The laser provides high energy into restricted area without contermination. The authors applied the dental laser welder for surface treatment of dental alloys. Various dental alloys are irradiated by laser with various atmosphere and laser power and their surface properties were estimated. The alloy phase and crystal stracture was changed by laser irradiation. Therefore, the laser heating was possible to provide the heat treatment effect in the restricted area. The laser radiation in the N2 atmosphere, nitride layer was formed on titanium surface and surface hardness was imporoved. Thus, the surface treatment of aimed area was possible by laser irradiation.To evaluate the biocompatibility, X-ray absorption fine structure (XAFS) analysis was applied for the analysis of titanium (Ti) in the human oral mucosa in contact with Ti dental implants from two different patients. Metallic Ti and an oxide (anatase) were detected. The metallic Ti was distributed in particulate form, which would be debris formed by the abrasion during the operation of implantation. The derivation of titanium oxides were assumed that the dissolved titanium was oxidized in the tissue and titanium dioxide was formed. The possibility of using XAFS for the analysis of the chemical state of rarely contained elements in biological tissue was suggested.

生物相容性受到材料表面物理和化学性质的强烈影响。与原始金属相比，金属碳化物和氮化物化学稳定。那么，它们的生物相容性也与原始金属相同或更好。近年来，高能激光被应用于金属牙科修复体的焊接。激光不间断地向限制区域提供高能量。作者应用牙科激光焊机对牙科合金进行表面处理。用不同气氛和激光功率的激光照射各种牙科合金，并评估它们的表面性能。激光照射改变了合金相和晶体结构。因此，激光加热可以在有限的区域内提供热处理效果。在N2气氛中激光照射，钛表面形成氮化层，表面硬度得到提高。因此，可以通过激光照射对目标区域进行表面处理。为了评估生物相容性，采用X射线吸收精细结构（XAFS）分析来分析与钛牙种植体接触的人体口腔粘膜中的钛（Ti）来自两个不同的患者。检测到金属Ti和氧化物（锐钛矿）。金属Ti以颗粒形式分布，是植入操作过程中磨损形成的碎片。二氧化钛的衍生假设溶解的钛在组织中被氧化并形成二氧化钛。提出了使用 XAFS 分析生物组织中很少含有的元素的化学状态的可能性。

项目成果

Three-dimensional topographic scanning electron microscope and Raman spectroscopic analyses of the irradiation effect on teeth by Nd : YAG, Er : YAG,and CO : lasers

Nd : YAG、Er : YAG 和 CO : 激光对牙齿照射效果的三维形貌扫描电镜和拉曼光谱分析

• 发表时间: 2004
• 作者: Yamada M.K.; Uo M.; Ohkawa S.; Akasaka T.; Watari F.
• 通讯作者: Watari F.

Cytotoxicity and bonding properties of denta 1 ceramics

denta 1陶瓷的细胞毒性和粘合性能

• 发表时间: 2003
• 作者: Uo M.; Sjogren G.; Sundh A.; Watari F.; Bergman M.; Lerner U.
• 通讯作者: Lerner U.

Tani K., Watari F., Uo M., Morota M.: "Discrimination between composite resin and teeth using fluorescence properties"Dental Materials Journal. 22. 569-580 (2003)

Tani K.、Watari F.、Uo M.、Morota M.：“利用荧光特性区分复合树脂和牙齿”《牙科材料杂志》。

Microparticle formation and its mechanism in single and double emulsion solvent evaporation.

单双乳液溶剂蒸发中微粒的形成及其机理。

• DOI: 10.1016/j.jconrel.2004.07.007
• 发表时间: 2004-09-30
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Iosif Daniel Rosca;F. Watari;M. Uo
• 通讯作者: M. Uo

Analysis of Titanium Dental Implants Surrounding Soft Tissue using X-ray Absorption Fine Structure (XAFS)

使用 X 射线吸收精细结构 (XAFS) 分析软组织周围的钛牙种植体

• 发表时间: 2005
• 作者: Uo M.; Asakura K.; Yokoyama A.; Totsuka Y.; Akasaka T.; Watari F.
• 通讯作者: Watari F.