The estimation of depression by brain imaging

通过脑成像评估抑郁症

• 批准号: 23700491
• 负责人: YAMADA Takashi
• 金额: $ 2.66万
• 依托单位: Chubu University (2012-2013)National Center for Geriatrics and Gerontology (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700491/
• 关键词: 脳イメージング; 動物PET; うつ病; 加齢性精神疾患; セロトニン; ドーパミン; PET

In this study, we estimated an effectiveness of PET imaging for evaluating depression and we measured brain monoamine component, especially serotonin transporter. We used serotonin transpoter ligand 11C-DASB, abtained rat brain serotonin transporter image by some age group. Then, we suggested empression of serotonin transporter was differ in some age group, and the difference could distinguish by brain imaging. In addition, we compared with brain setoronin transporter image and amount of brain serotonin, transporter expression level in rats which received physical stress. From these results, we suggested that PET imaging would be effectual tool for brain serotonin component and estimating the condition of the depression.

在这项研究中，我们估计了PET成像评估抑郁症的有效性，并测量了脑单胺成分，尤其是5-羟色胺转运蛋白。我们使用了5-羟色胺转蛋白配体11C-DASB，通过某个年龄组为大鼠脑5-羟色胺转运蛋白图像。然后，我们建议在某些年龄段中羟色胺转运蛋白的弹性有所不同，差异可以通过脑成像区分。此外，我们将脑塞多洛烯蛋白转运蛋白的图像和脑血清素的数量，受到身体应激的大鼠的转运蛋白表达水平进行了比较。从这些结果中，我们建议PET成像将是脑血清素成分的有效工具，并估计抑郁症的状况。

项目成果

Measurement of serotonin transporter in rat brain by [11C]DASB - Preliminary study with high resolution animal PET scanner.

通过 [11C]DASB 测量大鼠大脑中的血清素转运蛋白 - 使用高分辨率动物 PET 扫描仪进行初步研究。

• 发表时间: 2011
• 作者: Takashi Yamada;Kentaro Hatano;Kengo Ito.
• 通讯作者: Kengo Ito.