Constructive approach to pathological mechanisms for disturbance of sense of agency

代理感障碍病理机制的建设性方法

• 批准号: 23700279
• 负责人: YAMASHITA Yuichi
• 金额: $ 2.83万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700279/
• 关键词: 脳・神経; 神経科学; 認知科学; ニューラルネットワーク; 意思作用感; 統合失調症; 精神疾患; 病態認知神経科学; 計算論的神経科学; ロボティクス

We hypothesize that altered awareness of action in schizophrenia may arise from disturbance of the forward model originating in functional dysconncetion in a hierarchical neural network. The proposed idea was tested through a neuro-robotic experiment using a hierarchical neural network model connected to a humanoid robot interacting with a physical environment. The results demonstrate that not only top-down forward dynamics, but also bottom-up regression processes driven by prediction error are important mechanisms for flexible adaptation to unpredictable changes in environment. In the simulated functional disconnection, in contrast to the normal condition, it turns out that this bottom-up regression process generates unnecessary modulatory signals which may induce altered awareness of action in patients. These results suggest that the proposed hypothesis may provide novel insight for understanding the pathological mechanisms of schizophrenia.

我们假设，精神分裂症的作用意识的改变可能是由于对层次神经网络中功能性障碍性的远期模型的干扰引起的。通过使用与人形机器人与物理环境相互作用的类人体机器人相互作用的分层神经网络模型，通过神经动物实验进行了测试。结果表明，不仅自上而下的向前动力学，而且预测误差驱动的自下而上的回归过程是灵活适应环境中不可预测变化的重要机制。与正常情况相反，在模拟的功能断开连接中，事实证明，这种自下而上的回归过程会产生不必要的调节信号，这可能会导致患者的作用意识改变。这些结果表明，所提出的假设可以为理解精神分裂症的病理机制提供新的见解。

项目成果

Suicide attempt correlate with delusional content in the first episode of schizophrenia

精神分裂症首次发作时自杀未遂与妄想内容相关

• 发表时间: 2013
• 作者: Matsuoka J;Yamashita Y;Baba M;Funada E;Suyama M;Itokawa M;Izawa R
• 通讯作者: Izawa R

Prediction error disequilibrium in schizophrenia

精神分裂症的预测误差不平衡

• 发表时间: 2013
• 作者: Yamashita Y;Izawa R;Tani J
• 通讯作者: Tani J

感情の認知と遷移

情绪识别和转变

• 发表时间: 2013
• 期刊: 生物の科学遺伝
• 作者: 藤村友美;中谷裕教;山下祐一
• 通讯作者: 山下祐一

Self-organized functional hierarchy through multiple timescale:neuro-dynamical accounts for behavioral compositionality. in Computational and Robotic Models of the Hierarchical Organization of Behavior.

通过多个时间尺度的自组织功能层次结构：神经动力学解释行为组合性。

• 发表时间: 2013
• 作者: Yamashita Y;Tani J.
• 通讯作者: Tani J.

Sensitivity to social context in detection of facial expression change

检测面部表情变化时对社会背景的敏感性

• 发表时间: 2012
• 作者: Yamashita Y;Honda M;Okanoya K;Okada M
• 通讯作者: Okada M