Pathophysiology of myelodyspoastic syndrome - network between bone marrow and nervus system

骨髓增生异常综合征的病理生理学 - 骨髓与神经系统之间的网络

• 批准号: 23659482
• 负责人: CHIBA Shigeru
• 金额: $ 2.33万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659482/
• 关键词: ネスチン; 骨髄異形成症候群; 骨髄異形性症候群; Nestin; 癌; 細胞・組織

In normal human bone marrow, spindle-shaped nestin-expressing cells, distinct from endothelial cells, were shown as the vascular vessel wall-constituting cells. In contrast, such a structure was disarranged in the bone marrow of myelodyspoastic syndrome patients. We further found abnormalities in fetal liver hematopoiesis in mice with knocked-down Notch signaling in cells expressing nestin, implying important roles of Notch signaling in nestin-expressing stromal cells in hematopoiesis.

在正常人骨髓中，与内皮细胞不同，纺锤形表达巢蛋白的细胞被显示为血管壁构成细胞。相比之下，骨髓增生异常综合征患者的骨髓中这种结构被打乱。我们进一步发现表达巢蛋白的细胞中Notch信号被敲低的小鼠胎儿肝脏造血异常，这意味着表达巢蛋白的基质细胞中Notch信号在造血中的重要作用。

项目成果

Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis

日本成人伯基特淋巴瘤患者采用改良 LMB 方案的治疗结果：单中心回顾性分析

• 发表时间: 2011
• 期刊: J Clin Exp Hematop
• 影响因子: 1.5
• 作者: Nishikii H;Nakamura N;Kondo Y;Okoshi Y;Suzukawa K;Hasegawa Y;Yokoyama Y;Sakata-Yanagimoto M;Enami T;Noguchi M;Chiba S
• 通讯作者: Chiba S

Spectrum of gene mutations in myelodysplastic syndromes revealed by whole-exome sequencing

全外显子组测序揭示骨髓增生异常综合征的基因突变谱

• 发表时间: 2012
• 作者: Nakamura M;Kitaura J;Enomoto Y;Lu Y;Nishimura K;Isobe M;Ozaki K;Komeno Y;Nakahara F;Oki T;Kume H;Homma Y and Kitamura T;Kenichi Yoshida
• 通讯作者: Kenichi Yoshida

Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria

• DOI: 10.1111/j.1365-2141.2010.08505.x
• 发表时间: 2011-03-01
• 期刊: BRITISH JOURNAL OF HAEMATOLOGY
• 影响因子: 6.5
• 作者: Kozuma, Yukinori;Sawahata, Yuka;Ninomiya, Haruhiko
• 通讯作者: Ninomiya, Haruhiko

国際的な臍帯血バンクネットワークを基盤とした臍帯血のやり取り

基于国际脐带血库网络的脐带血交换

• 发表时间: 2012
• 作者: 栗田尚樹;Francesco Frassoni;Nicoletta Sacchi;Claudia Cossu;Alberto Serio;Canieda Cilloni;千葉滋;Maria Podesta
• 通讯作者: Maria Podesta

The LRF transcription factor regulates mature B cell development and the germinal center response in mice

• DOI: 10.1172/jci45682
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Sakurai, Nagisa;Maeda, Manami;Maeda, Takahiro
• 通讯作者: Maeda, Takahiro