Identification of Helicobacter pylori-derived ncRNAs that induce host response disruption

鉴定诱导宿主反应中断的幽门螺杆菌衍生的 ncRNA

• 批准号: 23659220
• 负责人: MIMURO Hitomi
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659220/
• 关键词: 細菌; 感染症; ヘリコバクターピロリ

The aim of this study was to explore effector RNAs in Helicobacter pylori, which disrupt host responses. In silico analysis revealed that there is no effector RNAs possessing human microRNA-like conformation in H. pylori genome sequence. We found that the levels of several microRNAs were increased independent of the bacterial RNA transfer in H. pylori-infected epithelial cells. The effect of the identified microRNA increased in H. pylori-infected cells was estimated as the cell proliferation of host cells.

本研究的目的是探索幽门螺杆菌中扰乱宿主反应的效应子 RNA。计算机分析表明，幽门螺杆菌基因组序列中不存在具有人类 microRNA 样构象的效应 RNA。我们发现，在幽门螺杆菌感染的上皮细胞中，几种 microRNA 的水平增加，与细菌 RNA 转移无关。已鉴定的 microRNA 在幽门螺杆菌感染的细胞中增加的效果被估计为宿主细胞的细胞增殖。

项目成果

Control of host cell responses by Helicobacter pylori infection

幽门螺杆菌感染控制宿主细胞反应

• 发表时间: 2012
• 作者: Hitomi Mimuro;Kotaro Kiga;and Chihiro Sasakawa
• 通讯作者: and Chihiro Sasakawa