Mechanisms of persistent Helicobacter pylori infection

幽门螺杆菌持续感染的机制

• 批准号: 23390102
• 负责人: MIMURO Hitomi
• 金额: $ 12.65万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390102/
• 关键词: 細菌; 感染; 微生物; ヘリコバクターピロリ; 感染症; 細菌; 感染; 微生物; ヘリコバクターピロリ; 感染症

The aim of this study was to obtain a comprehensive understanding of the mechanisms underlying Helicobacter pylori (Hp)-induced long-term colonization in stomach. We focused on three aspects of the interplay between Hp and the host: the expression dynamics of Hp, the reaction dynamics at Peyer's patches, and host responses. As a result, we identified candidates of bacterial factors involved in bacterial association with Peyer's patches. We also found that epigenetic silencing of miRNA-X plays a key role in gastric disease progression in response to persistent Hp infection.

这项研究的目的是对幽门螺杆菌（HP）诱导的胃中的长期定植的机制进行全面了解。我们专注于HP与主机之间相互作用的三个方面：HP的表达动力学，Peyer斑块的反应动力学以及主机响应。结果，我们确定了与Peyer斑块相关的细菌因素的候选者。我们还发现，miRNA-X的表观遗传沉默在响应持续的HP感染中在胃病进展中起关键作用。