Enhanced arteriogenesis for prevention of ischemic brain damage

增强动脉生成以预防缺血性脑损伤

• 批准号: 23790980
• 负责人: ISHIBASHI Satoru
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790980/
• 关键词: 脳梗塞; 動物モデル; 動脈新生; 慢性低灌流; ずり応力; FGF-2; 脳血管障害; 血管新生; 慢性低還流; 再生医療

Positive outward remodeling of pre-existing of De-novo collateral arteries into functional conductance arteries, arteriogenesis, is a major endogenous rescue mechanism to prevent ischemic damage after stroke. We, here, investigated the mechanism of arteriogenesis or examined effect on ischemia brain damage by means of promoting arteriogenesis with basic fibroblast growth factor 2 (FGF-2) in experimental chronic brain hypoperfused mice model.Brain hypoperfusion significantly increased the diameter of leptomeningeal arteries,and the number of proliferating endothelial or smooth muscle cells in the arteries. Hypoperfused or sham animals underwent subsequent ipsilateral middle cerebral artery occlusion, and infarct volume was assessed. The total infarction volume was significantly decreased in hypoperfused mice than sham-operated animals. FGF-2 administration enhanced collateral artery growth and further reduced infarction volume, resulting in long-term functional recovery.

向外重塑，将脱诺沃侧支动脉预先存在于功能电导动脉中，动脉生成是一种主要的内源性救援机制，可预防中风后缺血性损害。在这里，我们通过促进动脉生成的作用来研究动脉生成的机制或在实验性的慢性脑缺化小鼠模型中促进动脉生成的作用。下型动物或假动物接受了随后的同侧中大脑动脉闭塞，并评估了梗塞体积。与假手术动物相比，垂直小鼠的总梗塞体积显着降低。 FGF-2给药增强了侧支动脉的生长，并进一步减少了梗塞量，从而导致长期功能恢复。

项目成果

東京医科歯科大学神経内科website

东京医科齿科大学神经内科主页

Posterior Cerebral Artery Laterality Sign on MRA Predicts Long-Term Functional Outcome in Patients with Middle Cerebral Artery Occlusion

MRA 上的大脑后动脉偏侧征可预测大脑中动脉闭塞患者的长期功能结果

• 作者: Masahiko Ichijo;Kazunori Miki
• 通讯作者: Kazunori Miki

東京医科歯科大学 脳神経病態学

东京医科齿科大学神经病理学系

脳梗塞後の制御性T細胞誘導がneurovascularnicheに与える効果の検討

脑梗死后调节性T细胞诱导对神经血管微环境的影响研究

• 发表时间: 2011
• 作者: Abe M;Sano Y;Maeda T;Shimizu F;Kashiwamura Y;Haruki H;Saito K;Tasaki A;Kawai M;Terasaki T;Kanda T;Kira J et al;石橋哲
• 通讯作者: 石橋哲

Distal hyperintense vessels on FLAIR images predict large-artery stenosis in patients with transient ischemic attack

• DOI: 10.1007/s00234-012-1092-y
• 发表时间: 2013-02-01
• 期刊: NEURORADIOLOGY
• 影响因子: 2.8
• 作者: Yoshioka, Kotaro;Ishibashi, Satoru;Mizusawa, Hidehiro
• 通讯作者: Mizusawa, Hidehiro