Novel administration of anti-VEGF antibody for retinopathy of prematurity

抗 VEGF 抗体治疗早产儿视网膜病变的新方法

• 批准号: 23792006
• 负责人: SAITO Yuta
• 金额: $ 2.58万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792006/
• 关键词: 薬理学; 未熟児網膜症; 血管内皮増殖因子; 抗VEGF抗体; 薬物動態; VEGF; IGF-1; OIR; 網膜毒性

We investigated that the effect, pharmacokinetics and toxicity of subconjunctival or intravitreal injections of anti-VEGF antibody for OIR rat model. Subconjunctival injection of anti-VEGF suppressed the retinal neovascularization in OIR rat model; even the effect was smaller than that of intravitreal injection. The antibody escapedinto systemic circulation, thus it affected fellow eyes. The toxicity for retinas was not detected.

我们研究了结膜下或玻璃体内注射抗 VEGF 抗体对 OIR 大鼠模型的作用、药代动力学和毒性。结膜下注射抗VEGF药物抑制OIR大鼠模型视网膜新生血管形成；甚至其效果还小于玻璃体内注射。抗体逃逸到体循环中，从而影响了其他人的眼睛。未检测到对视网膜的毒性。

项目成果

高濃度酸素負荷虚血網膜症ラットに対する抗VEGF抗体結膜下投与の効果の検討

高氧应激下结膜下注射抗VEGF抗体对缺血性视网膜病变大鼠的影响

• 发表时间: 2011
• 作者: 蒲山順吉;齋藤雄太;植田俊彦;中西孝子;松原 倫子;和田悦洋;久光正;小出良平
• 通讯作者: 小出良平

Effects of Subconjunctival Injection of Anti-Vascular Endothelial Growth Factor Antibody on Oxygen-Induced Ischemic Retinopathy in a Neonatal Rat Model

结膜下注射抗血管内皮生长因子抗体对新生大鼠模型氧诱导缺血性视网膜病变的影响

• 发表时间: 2012
• 期刊: The Showa University Journal of Medical Sciences
• 作者: Kabayama J;Saito Y;Nakanishi-Ueda T;Ueda T;Matsubara M;Wada Y;Okawada H;Hisamitsu T;Koide R
• 通讯作者: Koide R

Effects of Subconjunctival Injection of anti-VEGF Antibody on Oxygen-induced Retinal Neovascularization of the Neonatal Rat Model

结膜下注射抗VEGF抗体对氧诱导新生大鼠视网膜新生血管的影响

• 发表时间: 2011
• 作者: Yuta Saito;Takako Nakanishi-Ueda;Toshihiko Ueda;Yoshihiro Wada;Hajime Yasuhara;Ryohei Koide
• 通讯作者: Ryohei Koide