Study of the mechanism of obesity-associated infertility in male and search for nutrient component improving obesity associated infertility

男性肥胖不育机制研究及改善肥胖不育的营养成分

• 批准号: 23617023
• 负责人: SUZUKI Toshikazu
• 金额: $ 3.58万
• 依托单位: Wayo Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23617023/
• 关键词: 雄性不妊; 肥満; 高脂肪食; 精巣; 精巣上体; 遺伝子解析

Human studies have shown a direct relationship between obesity and infertility in men and women. In the present study, we examined the mechanism of infertility by high fat diet-induced obesity in male mice. In addition, we examined whether L-carnitine can improve male infertility with diet-induced obesity. High fat diet-obesity resulted in decreased sperm motility and reduction in pregnancies of female partners. L-carntine supplementation itself did not seem to improve obesity-associated male infertility in male mice. Gene expression analysis of cauda epididymides suggested that DNA damage is increased in the sperm cells during spermatogenesis and/or sperm maturation in diet-induced obesity male mice and decreased expression of piRNA might be involved in the increased DNA damage in sperm.

人类研究表明，男性和女人的肥胖与不育症之间存在直接关系。在本研究中，我们检查了高脂肪饮食诱导的雄性小鼠肥胖的不孕机制。此外，我们检查了L-肉碱是否可以通过饮食诱导的肥胖来改善男性不育症。高脂肪饮食肥胖导致精子运动降低和女性伴侣怀孕的降低。 l-康涅丁补充本身似乎并没有改善雄性小鼠与肥胖相关的雄性不育症。 Cauda附生酶的基因表达分析表明，精子发生和/或精子成熟在饮食诱导的肥胖雄性小鼠中的精子细胞中增加了DNA损伤，而PIRNA的表达降低可能与精子中的DNA损伤增加有关。

项目成果

10． Blood levels of the micronutrient zinc decrease with advancing age in normally nourished elderly persons

十。

• 发表时间: 2012
• 作者: Takahashi M;Takagi A;Suzuki T;Matsumoto H
• 通讯作者: Matsumoto H

11． Appliance of domiciliary nutrition instruction method for the elderly people requiring long-term care in Japan

11.

• 发表时间: 2012
• 作者: Rusu-Udagawa K;Suzuki T;Yanagisawa Y
• 通讯作者: Yanagisawa Y

Appliance of domiciliary nutrition instruction method for the elderly people requiring long-term care in Japan

日本长期护理老年人家庭营养指导方法的应用

• 发表时间: 2012
• 作者: Koko Udagawa-Rusu;Toshikazu Suzuki;Yukie Yanagisawa
• 通讯作者: Yukie Yanagisawa

Catechin-rich green tea extract increased serum cholesterol levels in normal diet- and high fat diet-fed rats

富含儿茶素的绿茶提取物增加正常饮食和高脂肪饮食喂养的大鼠的血清胆固醇水平

• 发表时间: 2012
• 作者: Toshikazu Suzuki;Ayumi Takagi;Michiyo Takahashi
• 通讯作者: Michiyo Takahashi

Long-term hospitalized elderly people have lowered L-carnitine and coenzyme Q10 in blood than independent elderly people

长期住院老人血液中左旋肉碱、辅酶Q10较独立老人降低

• 发表时间: 2014
• 作者: Michiyo Takahashi;Toshikazu Suzuki;Hikaru Matsumoto;Hitoshi Nukada;Naotaka Hasizume
• 通讯作者: Naotaka Hasizume