Study on mechanism of vital staining with iodine solution and disorder of glycogen metabolism in oral squamous cell carcinoma

口腔鳞癌碘液活体染色及糖原代谢紊乱机制研究

• 批准号: 23592959
• 负责人: KURITA HIROSHI
• 金额: $ 3.24万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592959/
• 关键词: ヨード染色; グリコーゲン; 口腔扁平上皮癌; 生体染色; 糖代謝; ルゴール染色; 臨床腫瘍学; 口腔粘膜

Vital staining with iodine solution has been used in diagnosis and treatment of oral squamous cell carcinoma (OSCC). The results of this study suggested that Iodine infiltrated and reacted with intra-cell glycogen (full- and surrounded- type) mainly in the upper superficial layer of the non-keratinized epithelium. And it was also suggested that OSCC cells showed significant increase of glucose uptake and accelerated glycogen breakdown.

用碘溶液染色已用于诊断和治疗口服鳞状细胞癌（OSCC）。这项研究的结果表明，碘与细胞内糖原（全型和周围）反应主要是在非甲基化上皮的上层层中。还建议OSCC细胞显示出葡萄糖摄取和加速糖原崩溃的显着增加。

项目成果

Vital staining with iodine solution and glycogen metabolism in oral squamous cell carcinoma

口腔鳞状细胞癌的碘溶液活体染色与糖原代谢

• 发表时间: 2013
• 作者: Aizawa H;Xiao T;Kobayashi H;Shimane T;Kurita H
• 通讯作者: Kurita H

口腔扁平上皮癌におけるヨード生体染色機序の解明2.上皮に染みこむ部位とグリコーゲン分布の関連について

口腔鳞状细胞癌碘活体染色机制的阐明2.上皮渗透部位与糖原分布的关系

• 发表时间: 2012
• 作者: Inoue S.;Arai N.;Tomihara K.;Noguchi M.;佐藤英和,莇生田整治,臼田慎,森田麻友,山田有佳,小高利絵,中川種昭,角田和之;河合穂高，辻極秀次，伊藤 聡，中野敬介，于 淞，川上敏行，長塚 仁;肖鉄鵬,栗田浩,西牧史洋,嶋根哲,飯島響,鎌田孝広,小池剛史
• 通讯作者: 肖鉄鵬,栗田浩,西牧史洋,嶋根哲,飯島響,鎌田孝広,小池剛史

Iodine penetration and glycogen distribution in vital staining of oral mucosa with iodine solution

碘溶液口腔粘膜活体染色中的碘渗透和糖原分布

• DOI: 10.1016/j.oooo.2014.02.008
• 发表时间: 2014
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol
• 作者: Xiao T;Kurita H;Li X;Qi F;Shimane T;Aizawa H;Uehara S
• 通讯作者: Uehara S

Vital staining with iodine solution in oral cancer: iodine infiltration, cell proliferation, and glucose transporter 1

• DOI: 10.1007/s10147-012-0450-4
• 发表时间: 2013-10
• 期刊: International Journal of Clinical Oncology
• 影响因子: 3.3
• 作者: T. Xiao;H. Kurita;T. Shimane;Y. Nakanishi;T. Koike

口腔扁平上皮癌におけるグリコーゲンに関する検討

口腔鳞状细胞癌糖原的研究

• 发表时间: 2013
• 作者: Tomihara K;Inoue S;Takei R;Imaue S;Arai N;Noguchi M;三友啓介,角田和之,佐藤英和,加藤伸,山上淳,天谷雅行,中川種昭,河奈裕正;相澤仁志,肖鉄鵬,小林啓一,小池剛史,嶋根哲,斉芳芳,栗田浩
• 通讯作者: 相澤仁志,肖鉄鵬,小林啓一,小池剛史,嶋根哲,斉芳芳,栗田浩