Effects of oral sensation and orexigenic peptide stimulus on sleep and spatial memory
口腔感觉和食欲肽刺激对睡眠和空间记忆的影响
基本信息
- 批准号:23592921
- 负责人:
- 金额:$ 3.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2013
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The consecutive odor stimulation of Osmanthus fragrans promoted the spatial memory accompanied with decrease of the expression of Orexin and number of orexin-immunoreactive neurons in the hypothalamus, in addition to the loss of body weight. Zinc deficiency, might be related to taste disorder, demonstrated the characteristic changes of feeding behavior as well as decreasing of spatial memory. Immunohistological study showed an increase of GFAP-positive neurons in hippocampus as well. Further investigation revealed more decline effect in the combined condition of Zinc deficiency and deterioration of masticatory function by tooth extraction.These results suggest that orofacial sensory inputs such as smell, taste and chewing might have a potent role for the regulation of spatial memory.
桂花的连续气味刺激促进了空间记忆,除了体重减轻之外,还伴随着下丘脑中食欲素表达和食欲素免疫反应性神经元数量的减少。缺锌可能与味觉障碍有关,表现出摄食行为的特征性变化以及空间记忆的下降。免疫组织学研究显示海马中 GFAP 阳性神经元也有所增加。进一步的研究表明,缺锌和拔牙导致的咀嚼功能恶化的综合作用更为明显。这些结果表明,嗅觉、味觉和咀嚼等口面部感觉输入可能对空间记忆的调节具有重要作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The odor of Osmanthus fragrans attenuates food intake.
- DOI:10.1038/srep01518
- 发表时间:2013
- 期刊:
- 影响因子:4.6
- 作者:Yamamoto, Takashi;Inui, Tadashi;Tsuji, Tadataka
- 通讯作者:Tsuji, Tadataka
桂花の匂い刺激が摂食関連ペプチドの発現および咀嚼筋活動を含めた摂食行動特性へ与える影響
Keika气味刺激对摄食相关肽表达和摄食行为特征(包括咀嚼肌活动)的影响
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:辻忠孝;乾賢;木田久美子;Bakhshishayan Sanam;田中晋;佐藤耕一;古郷幹彦;山本隆
- 通讯作者:山本隆
Feeding behavior and spatial cognitive function in zinc-deficient rodents
缺锌啮齿动物的摄食行为和空间认知功能
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:木田久美子;辻忠孝;田中晋;古郷幹彦
- 通讯作者:古郷幹彦
桂花の匂いが摂食関連ペプチドの発現および咀嚼筋活動へ与える影響
柑橘气味对摄食相关肽表达和咀嚼肌活动的影响
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:Tsuji T;Tanaka S;Kogo M;Yamamoto T
- 通讯作者:Yamamoto T
Spatial memory and feeding behavior in zinc-deficient rodents
缺锌啮齿动物的空间记忆和进食行为
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:木田久美子;辻忠孝;Bakhshishayan Sanam;田中晋;山本隆;古郷幹彦
- 通讯作者:古郷幹彦
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