Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer

阐明EMT在头颈癌侵袭转移中的肿瘤干细胞激活机制

• 批准号: 23592537
• 负责人: OTA Ichiro
• 金额: $ 3.24万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592537/
• 关键词: 頭頸部がん; 癌幹細胞; 浸潤・転移; EMT; 頭頸部外科学

In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer.

在头颈癌细胞中，我们研究了Wnt/Snail信号通路是否可以诱导上皮间质转化、EMT，促进癌症干细胞的活化，增强癌细胞的侵袭和转移。结果，体内外研究发现Wnt/Snail信号通路可以通过EMT诱导癌症侵袭和转移。此外，Snail诱导的EMT细胞可以获得类似癌症干细胞的特性，例如增强治疗抵抗力和癌症干细胞标志物的表达。控制这些参与EMT的信号通路将有助于控制头颈癌的侵袭和转移。

项目成果

がん研究UP TO DATE 2013世界の基礎研究の動向

2013 年最新癌症研究 全球基础研究趋势

• 发表时间: 2013
• 作者: 桝井貴史;太田一郎;広中安佐子;武田麻衣子;笠井孝彦;山内晶世;土田澄代;高沢伸;細井裕司;太田一郎
• 通讯作者: 太田一郎

Combination of cetuximab and low-intensity ultrasound causes a synergistic enhancement in cell killing and an additive enhancement in apoptosis induction in human head and neck cancer cells

西妥昔单抗和低强度超声的组合可协同增强细胞杀伤作用，并进一步增强人头颈癌细胞的凋亡诱导作用

• 发表时间: 2011
• 作者: Takashi Masui;他3名
• 通讯作者: 他3名

超音波照射によるEGFRをターゲットにした分子標的治療Cetuximabの増感効果の検討

超声波照射检查西妥昔单抗靶向EGFR的分子靶向治疗的增敏作用

• 发表时间: 2012
• 作者: 太田一郎;桝井貴史;神野正敏;家根旦有;細井裕司
• 通讯作者: 細井裕司

Sentinel Lymph Node Detection in Patients with Oral Cancer by MR Lymphography using Superparamagnetic Iron Oxide

使用超顺磁性氧化铁进行磁共振淋巴成像检测口腔癌患者的前哨淋巴结

• 发表时间: 2013
• 期刊: The Open Otorhinolaryngology Journal
• 作者: Uemura H;Ota I;Fujii T;Suzuki M;Sakai M;Nakanishi K;Tomita Y;Noguchi A;Hosoi H;Yoshino K
• 通讯作者: Yoshino K

Snail1 regulates MMP- dependent invasive activities through cancer cell EMT programs in head and neck cancer cells

Snail1 通过头颈癌细胞中的癌细胞 EMT 程序调节 MMP 依赖性侵袭活动

• 发表时间: 2012
• 作者: Ota I;Masui T;Yane K;Okamoto N;Hosoi H
• 通讯作者: Hosoi H