Mechanism of cell death and development of a new therapy against noise-induced hearing loss

细胞死亡机制和抗噪声性听力损失新疗法的开发

• 批准号: 23592482
• 负责人: YAMASHITA Daisuke
• 金额: $ 3.24万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592482/
• 关键词: 内耳; 再生; アポトーシス; 音響外傷; 細胞死; メタボローム解析

We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function / inner ear morphology were obtained.

我们首先制作了因强烈噪音而导致听力损失的动物模型。在听力损失动物模型中，我们阐明了导致内毛细胞死亡（凋亡）的机制。最后，基于这些结果，我们探讨了通过各种途径治疗听力损失的方法，并获得了可能治愈听力功能/内耳形态两侧听力损失的结果。

项目成果

耳鼻咽喉科領域のジェネリック薬品特集・耳鼻咽喉科領域のジェネリック薬品とサプリメント

耳鼻咽喉科领域仿制药专题/耳鼻喉科领域仿制药和补充剂

• 发表时间: 2013
• 作者: 白馬 伸洋;岡田 昌浩;暁 清文;山下大介
• 通讯作者: 山下大介

Managenet outcome following lateral temporal bone resection for cancer of external auditory canal

外耳道癌外侧颞骨切除术后的管理结果

• 发表时间: 2012
• 作者: Hasegawa S;Yamashita D;Fujita T;Nibu KI.
• 通讯作者: Nibu KI.

手足口病特集口腔内ウィルス感染の診断と治療

手足口病专题：口腔病毒感染的诊治

• 发表时间: 2011
• 作者: 山下大介;丹生健一
• 通讯作者: 丹生健一

Metabolome analysis of inner ear fluid in guinea pigs cochlea after intense noise

强噪声后豚鼠耳蜗内耳液的代谢组分析

• 发表时间: 2014
• 作者: Yamashita D;Fikuda Y;Fujita T;Shinomiya H;Inokuchi G;Hasegawa S;Otsuki N;Nibu KI.
• 通讯作者: Nibu KI.

Clinical feature and prognosis of hearing impairment due to meningeal carcinomatosis

脑膜癌病所致听力障碍的临床特征及预后

• 发表时间: 2013
• 作者: Inokuchi G;Komatsu H;Sawada N;Yamashita D;Kumoi K
• 通讯作者: Kumoi K