Role of RAGE in peri-operative lung injury

RAGE 在围手术期肺损伤中的作用

• 批准号: 23592076
• 负责人: SAKUMA Tsutomu
• 金额: $ 3.33万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592076/
• 关键词: RAGE; 肺傷害; 肺癌; 慢性閉塞性肺疾患; 周術期; 肺胞水分クリアランス; PPAR; 肺水腫; 肺胞上皮細胞; 再潅流肺傷害; ヒト切除肺; 肺嚢胞; 虚血再潅流肺傷害

The expression of receptor for advanced glycation end products (RAGE) was examined in the excised human lungs. The expression of type 1 alveolar cells and alveolar macrophage increased in chronic obstructive pulmonary disease (COPD). The expression was correlated negatively with forced expiratory volume in one second. RAGE expression was not associated with smoking index. In lung cancer, RAGE was highly expressed in both small cell lung cancer and adenocarcinoma. Less differentiated adenocarcinoma expressed RAGE more frequently than well differentiated adenocarcinoma. The enhanced expression of RAGE was present in non-mucinous adenocarcinoma. Adenocarcinoma in the advanced stages tended to show a higher expression score for RAGE. The expression of RAGE inversely correlated with that of AGEs, although it did not show any relationship with the expression of HMGB-1 or S100A4. In rat lung, PPAR-gamma impaired alveolar fluid clearance probably through amiloride-sensitive sodium channel.

在切除的人肺中检查了晚期糖基化终末产物（RAGE）受体的表达。慢性阻塞性肺疾病 (COPD) 中 1 型肺泡细胞和肺泡巨噬细胞的表达增加。该表达与一秒用力呼气量呈负相关。 RAGE表达与吸烟指数无关。在肺癌中，RAGE 在小细胞肺癌和腺癌中均高表达。低分化腺癌比高分化腺癌更频繁地表达 RAGE。 RAGE 的表达增强出现在非粘液腺癌中。晚期腺癌往往表现出较高的 RAGE 表达评分。 RAGE的表达与AGEs的表达呈负相关，但与HMGB-1或S100A4的表达没有任何关系。在大鼠肺中，PPAR-γ 可能通过阿米洛利敏感的钠通道损害肺泡液清除率。

项目成果

Relationships between EGFR Mutation Status of Lung Cancer and Preoperative Factors - Are they Predictive?

• DOI: 10.7314/apjcp.2014.15.2.657
• 发表时间: 2014-01-01
• 期刊: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
• 作者: Usuda, Katsuo;Sagawa, Motoyasu;Sakuma, Tsutomu
• 通讯作者: Sakuma, Tsutomu