An analysis of intrahepatic lymphatic invasion in the patient with intrahepatic cholangiocarcinoma

肝内胆管癌患者肝内淋巴管侵犯分析

• 批准号: 23591979
• 负责人: UCHINAMI Hiroshi
• 金额: $ 3.24万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591979/
• 关键词: 肝内胆管癌; リンパ節転移; リンパ節郭清; 肝切除; 外科治療

Intrahepatic cholangiocarcinoma (ICC) arising from the intrahepatic bile duct is the second most frequent hepatic malignancy. Lymph node metastasis is known to be one of strong prognostic factors for survival in the patients undergoing curative resection for ICC. Therefore, the value of lymph node dissection during surgical treatment for ICC or indication of the resection for the patients who are preoperatively diagnosed to have metastatic lymph nodes is still in debate.In this study, we evaluated correlation between intrahepatic lymph vessel invasion and lymph node metastasis. We also investigated the outcomes of ICC patients following curative resection to analyze the influences of lymph node dissection on survival and recurrence.

肝内胆管引起的肝内胆管癌（ICC）是第二常见的肝恶性肿瘤。众所周知，淋巴结转移是接受ICC治疗切除术的患者生存的强烈预后因素之一。因此，在手术治疗期间淋巴结清扫术在ICC期间的淋巴结清除术或术前诊断为具有转移性淋巴结的患者的切除术仍在争论中。在这项研究中，我们评估了肝内淋巴淋巴细胞入侵和淋巴结转移的相关性。我们还研究了治疗切除后ICC患者的结果，以分析淋巴结清除对生存和复发的影响。

项目成果

Nrf2 activation protects the liver from ischemia/reperfusion injury in mice.

• DOI: 10.1097/sla.0000000000000287
• 发表时间: 2014-07
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Kudoh K;Uchinami H;Yoshioka M;Seki E;Yamamoto Y
• 通讯作者: Yamamoto Y