Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds.

使用小分子化合物抑制类风湿滑膜成纤维细胞中的 Janus 激酶/信号转导器和转录激活剂 (JAK/STAT) 信号通路。

• 批准号: 23591452
• 负责人: MIGITA Kiyoshi
• 金额: $ 3.33万
• 依托单位: Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-28 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591452/
• 关键词: 関節リウマチ; 滑膜細胞; シグナル伝達; ヤヌスキナーゼ; JAKs; STATs; サイトカインレセプター; 炎症性サイトカイン; JAKキナーゼ; STAT; JAK阻害剤; T細胞; CP690, 550

项目成果

Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Izumi M, Sakai T, Nakamura M, Motokawa S, Nakamura T, Kawakami A.Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis.

Migita K，Izumi Y，Jiuchi Y，Kozuru H，Kawahara C，Izumi M，Sakai T，Nakamura M，Motokawa S，Nakamura T，Kawakami A.Janus激酶抑制剂托法替尼治疗期间对循环血清淀粉样蛋白A和白细胞介素6的影响

• 发表时间: 2014
• 期刊: Clinical and experimental immunology
• 影响因子: 4.6
• 作者: Migita K;Izumi Y;Jiuchi Y;Kozuru H;Kawahara C;Izumi M;Sakai T;Nakamura M;Motokawa S;Nakamura T;Kawakami A.
• 通讯作者: Kawakami A.

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

• DOI: 10.1186/ar3333
• 发表时间: 2011-05-06
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Migita K;Komori A;Torigoshi T;Maeda Y;Izumi Y;Jiuchi Y;Miyashita T;Nakamura M;Motokawa S;Ishibashi H
• 通讯作者: Ishibashi H

Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine production.

• DOI: 10.1186/1471-2172-12-51
• 发表时间: 2011-08-31
• 期刊: BMC immunology
• 影响因子: 3
• 作者: Migita K;Miyashita T;Izumi Y;Koga T;Komori A;Maeda Y;Jiuchi Y;Aiba Y;Yamasaki S;Kawakami A;Nakamura M;Ishibashi H
• 通讯作者: Ishibashi H