Targeting of mesenchymal stem cell associated with colorectal cancer liver metastasis

间充质干细胞靶向与结直肠癌肝转移相关

• 批准号: 23590430
• 负责人: OHMORI Hitoshi
• 金额: $ 3.16万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590430/
• 关键词: 骨髄間葉系幹細胞; 大腸癌; 肝転移; 脂肪酸; 癌幹細胞; カロリー制限; TGFβ; HMGB1; リノール酸; エライジン酸; がん幹細胞

Bone marrow-derived mesenchymal stem cell (MSC) enhances cancer progression and metastasis, which is one of cutting edges of cancer research. We reported that cancer cells-secreted HMGB1 employs MSC into tumors. Their stemness is retained by HMGB1 and TGF-beta-containing biglycan, which is cancer-derived extracellular matrix. This tissue status is often observed microscopically in diabetes-complicated colorectal cancer metastasizing to the liver. Absorbance or neutralization of HMGB1 inhibits employing MSC to suppress tumor growth and metastasis. These findings suggest that the targeting of MSC might be a promising method against cancer progression.

骨髓来源的间充质干细胞（MSC）增强了癌症的进展和转移，这是癌症研究的切割边缘之一。我们报道了癌细胞分泌的HMGB1在肿瘤中使用MSC。它们的干性由HMGB1和含TGF-beta的Biglycan保留，这是癌症衍生的细胞外基质。在糖尿病复杂的结直肠癌转移到肝脏中，通常会观察到这种组织状态。 HMGB1的吸光度或中和抑制了使用MSC抑制肿瘤生长和转移的抑制。这些发现表明，MSC的靶向可能是针对癌症进展的有前途的方法。

项目成果

Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer

• DOI: 10.1002/ijc.27735
• 发表时间: 2013-02-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Shinagawa, Kei;Kitadai, Yasuhiko;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

アンギオテンシン系および血糖調節を標的とする大腸癌肝転移の抑制

靶向血管紧张素系统和血糖调节抑制结直肠癌肝转移

• 发表时间: 2012
• 作者: 大森 斉;羅 奕;川田元清;千原良友;國安弘基
• 通讯作者: 國安弘基

AGE induce RAGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet

AGE 在注射氧化偶氮甲烷并喂食高亚油酸和高葡萄糖饮食的 Fischer 344 大鼠的结肠粘膜中诱导 RAGE

• 发表时间: 2012
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Shimomoto T;Ohmori H
• 通讯作者: Ohmori H

Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model

• DOI: 10.1002/ijc.25812
• 发表时间: 2011-05-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Sumida, Tomonori;Kitadai, Yasuhiko;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

HMGB1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.

坏死细胞释放的 HMGB1 可增强化疗后存活的癌细胞的再生和转移。

• 发表时间: 2013
• 作者: Luo Y;Ohmori H (他6名)
• 通讯作者: Ohmori H (他6名)