FSH-R polymorphisms in women with infertility

不孕女性的 FSH-R 多态性

基本信息

批准号：
17390446
负责人：
MINEGISHI Takashi
金额：
$ 9.02万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390446/
关键词：
gene SNPs FSH-R LH-R ovulation induction FSH 不妊症シグナル伝達ゴナドトロピンレセプター

项目摘要

Follicle-stimulating hormone plays a crucial role during folliculogenesis by stimulating granulose-cell estrogen production through induction of aromatase activity. The action of FSH is mediated by the FSH receptor, which belongs to the large family of G-protein-coupled receptors. These receptors are characterized by a transmembrane domain consisting of seven membrane transversing α-helices connected by three extracellular and three intracellular loops. The FSH receptor gene is located at chromosome 2p2l to 16.In normogonadotropic normoestrogenic anovulatory infertility (World Health Organization class II), the response of the ovary to exogenous FSH administration varies considerably among patients. In a recent study, the individual FSH response dose for gonadotropin induction of ovulation in anovulatory infertile women could be predicted on the basis of initial screening characteristics, such as the initial FSH serum level. Recent observations in patients undergoing lVF suggest that the FSH receptor genotype is associated with different requirements for exogenous FSH.Recently, Sudo et al. reported a significant increase in the Ala/Thr 307 and Asn/Ser 680 genotype in a large cohort of women with PCOS.In normogonadotropic anovulatory infertile women, the overall frequency distribution for polymorphism at position 307 was 1% for Ala/Ala, 23% for Ala/Thr, and 66% for Thr/Thr ; for polymorphism at position 680, 66% for Asn/Asn, 23% for Asn/Ser, and 1% for Ser/Ser.

卵泡刺激素通过诱导芳香酶活性刺激颗粒细胞雌激素的产生，在卵泡发生过程中发挥着至关重要的作用。FSH 受体属于 G 蛋白偶联受体大家族。其特征是跨膜结构域由七个跨膜 α 螺旋组成，并通过三个细胞外环和三个细胞内环连接。FSH 受体基因位于染色体 2p2l 处。 16. 在正常促性腺激素正常雌性无排卵性不孕症（世界卫生组织 II 级）中，不同患者的卵巢对外源性 FSH 的反应差异很大。在最近的一项研究中，无排卵性不孕女性促性腺激素诱导排卵的个体 FSH 反应剂量可能为：根据初始筛查特征进行预测，例如接受 IVF 的患者的初始 FSH 血清水平最近的观察表明，FSH 受体基因型与不同的要求相关。最近，Sudo 等人报道了一大群患有 PCOS 的女性中 Ala/Thr 307 和 Asn/Ser 680 基因型显着增加。在促性腺激素正常的无排卵不孕女性中，位置 307 多态性的总体频率分布为对于位置多态性，Ala/Ala 为 1%，Ala/Thr 为 23%，Thr/Thr 为 66%； 680、Asn/Asn 为 66%、Asn/Ser 为 23%、Ser/Ser 为 1%。